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The purpose of the present study was to investigate the effects of granulocyte colony-stimulating factor (G-CSF) on neurodegeneration of optic nerve (ON) and retinal ganglion cells (RGCs) in a rat model of ON crush. The ONs of adult male Wistar rats (150-180 g) were crushed by a standardized method. The control eyes received a sham operation. G-CSF (100… (More)
Potassium (K) channels play a significant role in modulating human corporal smooth muscle tone, and thus, erectile capacity. Recent pharmacological studies indicate that the metabolically-regulated K channel (KATP) may be an important modulator of human penile erection with significant therapeutic potential. The goal of these initial studies, therefore, was… (More)
Patch clamp techniques in freshly isolated myocytes from human corpora have documented that the large conductance calcium-sensitive K channel (K(Ca)) subtype represents an important convergence point for the modulation of corporal smooth muscle tone, and therefore, erectile capacity. Other recent studies indicate a similar role for the K(Ca) channel in the… (More)
Axons of the central nervous system in adult mammals do not regenerate spontaneously after axotomy. To understand whether the optic nerve of adult mammals loses the intrinsic capability to regenerate after injury, we have studied the capability of neurite regeneration of retinal explant from adult rat after optic nerve axotomy in vitro. After experimental… (More)
A 39-year-old man had bilateral proptosis and blurred vision for I week. Computed tomography and magnetic resonance imaging showed signs of bilateral orbital pseudotumor, a suprasellar mass, and pulmonary infiltration. Biopsies from retrobulbar and bronchial sites showed similar inflammatory tissue. His disease resolved with pulsed corticosteroid therapy.
Neurite regeneration from central nervous tissue of mammalian has been demonstrated to occur in early postnatal stage but not in adult stage. To answer when the retinal explant of rat loses the neurite regeneration in vitro after birth, we have used tissue culture to study the neurite regeneration of retinal explant of Wistar rat at different ages. The… (More)
Gaze-evoked amaurosis is an uncommon but pathognomonic symptom of intrinsic orbital mass lesion. The symptom is easily neglected even by ophthalmologists. A 49-year-old woman had a two-year history of dimming vision in her right eye when she looked upward for a few seconds. On examination, her visual acuity was normal and without apparent proptosis. The… (More)