Hwang-Keun Jun

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PURPOSE Hepatocyte growth factor (HGF/SF) and its receptor c-Met have previously been shown to be up-regulated in multiple human cancers, including glioblastoma multiforme. To better understand if AMG 102, a fully human, anti-HGF/SF-neutralizing antibody, could be incorporated into current clinical practice, AMG 102 was tested preclinically in combination(More)
The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to be an appealing target for the treatment of human cancer. Herein, we report the synthesis, structure-activity relationships (SAR), X-ray cocrystal structure and in vivo(More)
Protein tyrosine phosphatases (PTPases) constitute a family of enzymes that catalyze the hydrolysis of a phosphate moiety from a phosphotyrosyl residue of a protein. Because of the biological importance of the reversible tyrosine phosphorylation, much research has been focused on the PTPases since its first identification in 1988. More than 70 PTPases have(More)
Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) is an accepted method to evaluate tumor perfusion and permeability and anti-vascular cancer therapies. However, there is no consensus on the vascular input function estimation method, which is critical to kinetic modeling and K trans estimation. This work proposes a response-derived input(More)
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