Hwa Ok Lee

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We have isolated a gene, the c subunit (ATP6L) of vacuolar H(+)-ATPase, involved in oxidative stress response. In this study, we examined the role of ATP6L and its molecular mechanisms in glial cell death induced by H(2)O(2). Expression of the ATP6L gene was increased by H(2)O(2) treatment in C6 glial cells. ATP6L siRNA-transfected C6 cells treated with(More)
Electrical logging-while-drilling (LWD) tools are commonly used in oil and gas exploration to estimate the conductivity (resistivity) of adjacent earth media. In general, earth media exhibit anisotropic conductivities. This implies that when LWD tools are used for deviated and horizontal drilling, the resulting borehole problem may include dipping-layered(More)
Golgi SNAP receptor complex 1 (GS28) has been implicated in vesicular transport between intra-Golgi networks and between endoplasmic reticulum (ER) and Golgi. Additional role(s) of GS28 within cells have not been well characterized. We observed decreased expression of GS28 in rat ischemic hippocampus. In this study, we examined the role of GS28 and its(More)
Logging-while-drilling (LWD) borehole sensors are used to provide real-time resistivity data of adjacent Earth formations for hydrocarbon exploration. This allows for an proactive adjustment of the dipping angle and azimuth direction of the drill, and hence geosteering capabilities. The analysis of borehole eccentricity effects on LWD sensor response in(More)
Previous studies reported that high levels of nitric oxide (NO) induce apoptotic cell death in osteoblasts. We examined molecular mechanisms of cytotoxic injury induced by sodium nitroprusside (SNP), a NO donor, in both glutathione (GSH)-depleted and control U2-OS osteoblasts. Cell viability was reduced by much lower effective concentrations of SNP in(More)
We examined the role of the c subunit (ATP6L) of vacuolar H(+) -ATPase and its molecular mechanisms in glial cell death induced by sodium nitroprusside (SNP). ATP6L siRNA-transfected cells treated with SNP showed a significant increase in cytotoxicity under glutathione (GSH)-depleted conditions after pretreatment with buthionine sulfoximine, but reduction(More)
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