Learn More
The ubiquity of mobile devices and the popularity of location-based-services have generated, for the first time, rich datasets of people's location information at a very high fidelity. These location datasets can be used to study people's behavior - for example, social studies have shown that people, who are seen together frequently at the same place and at(More)
Graph partitioning has attracted considerable attention due to its high practicality for real-world applications. It is particularly relevant to social networks because it enables the grouping of users into communities for market analysis and advertising purposes. In this paper, we introduce RMGP, a type of real-time multi-criteria graph partitioning for(More)
Myo1c is an unconventional myosin involved in cell signaling and membrane dynamics. Calcium binding to the regulatory-domain-associated calmodulin affects myo1c motor properties, but the kinetic details of this regulation are not fully understood. We performed actin gliding assays, ATPase measurements, fluorescence spectroscopy, and stopped-flow kinetics to(More)
Acetyl-CoA carboxylase (ACC) and propionyl-CoA carboxylase (PCC) catalyze the carboxylation of acetyl- and propionyl-CoA to generate malonyl- and methylmalonyl-CoA, respectively. Understanding the substrate specificity of ACC and PCC will (1) help in the development of novel structure-based inhibitors that are potential therapeutics against obesity, cancer,(More)
As the popularity of social networks is continuously growing, collected data about online social activities is becoming an important asset enabling many applications such as target advertising, sale promotions, and marketing campaigns. Although most social interactions are recorded through online activities, we believe that social experiences taking place(More)
ii I hereby declare that I am the sole author of this thesis. I authorize Ryerson University to lend this thesis to other institutions or individuals for the purpose of scholarly research. I further authorize Ryerson University to reproduce this thesis by photocopying or by other means, in total or in part, at the request of other institutions or(More)
This paper describes a system, Mr.Web, designed to interact with users over email to create and update Web pages. Our goal is that users interact with Mr.Web as if it were a human Webmaster. We collected 325 examples of people writing email requests to a Webmaster, and used this to generate the semantics of Mr.Web's email parser. The results of the survey(More)
DTGolog, a decision-theoretic agent programming language based on the situation calculus, was proposed to ease some of the computational difficulties associated with Markov Decision Processes (MDPs) by using natural ordering constraints on execution of actions. Using DTGolog, domain specific constraints on a set of policies can be expressed in a high-level(More)
The first committed step of fatty acid and polyketides biosynthesis, the biotin-dependent carboxylation of an acyl-CoA, is catalyzed by acyl-CoA carboxylases (ACCases) such as acetyl-CoA carboxylase (ACC) and propionyl-CoA carboxylase (PCC). ACC and PCC in Streptomyces coelicolor are homologue multisubunit complexes that can carboxylate different short(More)