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The blood-brain barrier (BBB) poses a huge challenge and is a serious issue in deciphering the pathophysiology of central nervous system disorders. Endothelial tight junctions play an essential role in maintaining the integrity of the BBB. Post-translational modifications (PTMs) in endothelial tight junction proteins are known to cause deleterious(More)
Pseudomonas aeruginosa is a ubiquitous environmental bacterium responsible for a variety of infections in humans, as well as in animal hosts. While the evolution of virulence in P. aeruginosa strains isolated from chronic lung infection in cystic fibrosis (CF) patients has been extensively studied, the virulence phenotype of P. aeruginosa isolated from(More)
Acinetobacter baumannii has emerged as a significant nosocomial pathogen during the last few years, exhibiting resistance to almost all major classes of antibiotics. Alternative treatment options such as vaccines tend to be most promising and cost effective approaches against this resistant pathogen. In the current study, we have explored the pan-genome of(More)
We present some studies on the mechanisms of pathogenesis based on experimental work and on its interpretation through a mathematical model. Using a collection of clinical strains of the opportunistic human pathogen Pseudomonas aeruginosa, we performed co-culture experiments with Dictyostelium amoebae, to investigate the two organisms' interaction,(More)
Autophagy, an evolutionary conserved multifaceted lysosome-mediated bulk degradation system, plays a vital role in liver pathologies including hepatocellular carcinoma (HCC). Post-translational modifications (PTMs) and genetic variations in autophagy components have emerged as significant determinants of autophagy related proteins. Identification of a(More)
Hepatocellular carcinoma (HCC) is the world's third most widespread cancer. Currently available circulating biomarkers for this silently progressing malignancy are not sufficiently specific and sensitive to meet all clinical needs. There is an imminent and pressing need for the identification of novel circulating biomarkers to increase disease-free survival(More)
Cellular immune responses (T cell responses) during hepatitis C virus (HCV) infection are significant factors for determining the outcome of infection. HCV adapts to host immune responses by inducing mutations in its genome at specific sites that are important for HLA processing/presentation. Moreover, HCV also adapts to resist potential drugs that are used(More)
The therapeutic efficacy of universal drug-delivery systems depends on their capability to escape the immune system by overcoming the biological barriers of the body and concentrate at target tissues to eradicate only diseased cells. Biologically synthesized nanoparticle systems possess almost all of these qualities and utilize their targeting ability(More)
Cellular homeostasis is a continuous phenomenon that if compromised can lead to several disorders including cancer. There is a need to understand the dynamics of cellular proliferation to get deeper insights into the prevalence of cancer. Mechanistic Target of Rapamycin (mTOR) is implicated as the central regulator of the metabolic pathway involved in(More)
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