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PURPOSE To create an average atlas of knee femoral cartilage morphology, to apply the atlas for quantitative assessment of osteoarthritis (OA), and to study localized sex differences. MATERIALS AND METHODS High-resolution 3D magnetic resonance imaging (MRI) data of the knee cartilage collected at 3 T as part of the Osteoarthritis Initiative (OAI) were(More)
Bone architectural information can be derived from structural indices calculated from high resolution magnetic resonance (MR) images. However, high resolution scans are time consuming and prone to motion artifacts and hence are not routinely feasible. The purpose of this study is to determine if a correlation exists between 3D structural indices calculated(More)
Osteoarthritis (OA) is a heterogeneous and multi-factorial disease characterized by the progressive loss of articular cartilage. Magnetic Resonance Imaging has been established as an accurate technique to assess cartilage damage through both cartilage morphology (volume and thickness) and cartilage water mobility (Spin-lattice relaxation, T2). The(More)
3D magnetic resonance imaging of the articular cartilage allows accurate morphological assessment of the cartilage with relevance for identifying osteoarthritis (OA) status and to monitor progression and response to treatment. We propose the creation of morphological atlases of the cartilage using normal subjects segregated by age, sex, and gender. These(More)
This investigation uses a multi disciplinary approach to standardize a non-invasive method for measuring human vocal tract morphology. A series of magnetic resonance imaging (MRI) scans are performed on the subject's vocal tract and a detailed three-dimensional model is created through image processing and computer modeling. The area and volume obtained(More)
An atlas of the cartilage was created using free form transformation of MR images of the cartilage from 20 subjects. The deformation required to move each voxel to its corresponding location in the atlas is used to determine the differences in shape between cartilages of subjects in a population. Based on these active shape models, it is possible to(More)
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