Husnia I. Marrif

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Astrocytes cope more readily with hypoxic insults than do neurons. We hypothesized that astrocytes can upregulate their glycolytic capacity, allowing anaerobic glycolysis to provide sufficient ATP for cell survival as well as for carrying out critical functions such as taking up glutamate. To test this hypothesis, astrocytes were subjected to hypoxia for 5(More)
The aqueous extract of Artemisia herba-alba Asso. (Compositae) produced an initial hyperglycaemia which was followed by hypoglycaemia in normoglycaemic and alloxan-treated rabbits and mice. The extract (0.39 g/kg) significantly increased gastrointestinal transit time and the reaction time to thermal stimuli but had no effect on the activity of alkaline(More)
We studied temperature homeostasis in male mice lacking all thyroid hormone receptor-alpha gene products (TRalpha-0/0). As other TRalpha-deficient mice, TRalpha-0/0 mice have lower core body temperature (T(C)) than cognate wild-type controls. We found that obligatory thermogenesis is normal in TRalpha-0/0 and that the lower T(C) at room temperature (RT,(More)
Uncertainty reigns over whether or not glutamate uptake in astrocytes leads to strong stimulation of glucose utilization, measured as accumulation of radioactive deoxyglucose-6-phosphate. This is an important issue, not only because glutamate is the major excitatory transmitter, but also because it has been postulated that glutamate-induced stimulation of(More)
Type two diabetes (T2D) is a challenging metabolic disorder for which a cure has not yet been found. Its etiology is associated with several phenomena, including significant loss of insulin-producing, beta cell (β cell) mass via progressive programmed cell death and disrupted cellular autophagy. In diabetes, the etiology of β cell death and the role of(More)
To define the role of mitochondrial glycerol-3-phosphate dehydrogenase (mGPD; EC 1.1.99.5) in energy balance and intermediary metabolism, we studied transgenic mice not expressing mGPD (mGPD-/-). These mice had approximately 14% lower blood glucose; approximately 50% higher serum glycerol; approximately 80% higher serum triglycerides; and at(More)
INTRODUCTION As diabetes progresses, a myriad of symptoms and signs appear in patients. Of these, distal symmetric peripheral neuropathy is one of the most devastating and common complications (Vinik et al., 2013). Etiology of diabetic neuropathy is complicated, and not fully understood. Yet strong evidence points at hyperglycemia and glycemic control as(More)
Thyroid hormones are the master regulator of body metabolism and growth. They act at molecular level to manipulate genes and cellular functions to balance the basic metabolic rate. They bind to superfamily of nuclear receptors that recognize discrete sequences of DNA and act as transcription factors (Renkawitz et al., 1996). At the cellular level, thyroid(More)
Thyroiditis is an inflammatory condition of the thyroid gland. It has been reported that thyroiditis is currently ranked the third autoimmune disease in the United States and has a staggering estimated prevalence of 21.8/100,000 (Burek et al., 2009). This is a well-established condition and many aspects of its etiology are also well known. According to the(More)