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Spatial estimations are increasingly used to estimate geocoded ambient particulate matter (PM) concentrations in epidemiologic studies because measures of daily PM concentrations are unavailable in most U.S. locations. This study was conducted to a) assess the feasibility of large-scale kriging estimations of daily residential-level ambient PM(More)
OBJECTIVE To investigate whether age-related macular degeneration (AMD) is associated with the development of myocardial infarction (MI) among elderly Americans. DESIGN Population-based cross-sectional and cohort study. PARTICIPANTS Five percent random sample of 2000 to 2003 Medicare enrollees. METHODS The cross-sectional study included the first(More)
OBJECTIVES This study examined the use of seclusion and mechanical restraint from 1990 to 2000 and the rate of staff injuries from patient assaults from 1998 to 2000 in a state hospital system. METHODS Records of patients older than 18 years who were civilly committed to one of the nine state hospitals in Pennsylvania were included in the analyses. Two(More)
The aims of this study were to: (i) assess gender differences of objective sleep patterns in a general population sample; (ii) evaluate the effects of menopause and hormone treatment (HT) on the sleep of the same cohort; and (iii) examine gender differences in sleep resilience towards external stressors. The participants were (i) 1324 subjects without sleep(More)
The CCC macro is presented for computation of the concordance correlation coefficient (CCC), a common measure of reproducibility. The macro has been produced in both SAS and R, and a detailed presentation of the macro input and output for the SAS program is included. The macro provides estimation of three versions of the CCC, as presented by Lin [L.I.-K.(More)
BACKGROUND We investigated whether the effect of air pollution on daily mortality is enhanced by high temperatures in Wuhan, China, using data from 2001 to 2004. Wuhan has been called an "oven" city because of its hot summers. Approximately 4.5 million permanent residents live in the 201-km(2) core area of the city. METHOD We used a generalized additive(More)
The concordance correlation coefficient (CCC) is a popular index for measuring the reproducibility of continuous variables. We examine two resampling approaches, permutation testing and the bootstrap, for conducting hypothesis tests on dependent CCCs obtained from the same sample. Resampling methods are flexible, require minimal marginal and joint(More)
Intravenous (i.v.) bisphosphonates relieve pain in conditions such as Paget's disease of bone, metastatic bone disease, and multiple myeloma. Based on positive findings from a prior case series, we conducted a randomized placebo-controlled study to assess the analgesic effect of i.v. pamidronate in subjects with chronic low back pain (CLBP) and evidence of(More)
BACKGROUND Although an independent association between hypothyroidism and coronary artery disease has been demonstrated, few studies have examined the association between hypothyroidism and peripheral arterial disease. In the current study, we test the hypothesis that there is an independent association between hypothyroidism and lower extremity arterial(More)