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Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism.
- T. Kao, Hung-Chi Tu, +4 authors T. Fu
- Biology, Medicine
- International journal of food microbiology
- 30 June 2010
GSE might serve as an effective natural alternative for the control of food poisoning caused by S. aureus with proper safety measure, indicated that GSE-induced perturbation in folate-mediated one-carbon metabolism has more profound impact on methionine cycle than on thymidine monophosphate synthesis. Expand
Pyridoxamine Supplementation Effectively Reverses the Abnormal Phenotypes of Zebrafish Larvae With PNPO Deficiency
- Po-Yuan Chen, Hung-Chi Tu, V. Schirch, M. Safo, T. Fu
- Biology, Medicine
- Front. Pharmacol.
- 20 September 2019
Zebrafish is suggested to be a promising PNPO-deficiency model for studying PLP homeostasis and drug therapy in vivo, and pyridoxamine (PM), another dietary form of vitamin B6, showed rescue effects even at a lower concentration than PLP, presenting a possible new therapeutic treatment for PN PO-deficient NEE. Expand
An automatic method to calculate heart rate from zebrafish larval cardiac videos
- Chia-Pin Kang, Hung-Chi Tu, T. Fu, Jhe-Ming Wu, Po-Hsun Chu, Darby Tien-Hao Chang
- Computer Science, Medicine
- BMC Bioinformatics
- 9 May 2018
This work developed a fully automatic method to calculate heart rate, an important parameter to analyze cardiac function, from videos, which does not lose accuracy while largely reducing the labor cost and uncertainty of manual counting. Expand
One crisis, diverse impacts—Tissue-specificity of folate deficiency-induced circulation defects in zebrafish larvae
The results of the current study provide an explanation for the inconsistent outcome observed clinically in patients suffering from folate deficiency and/or receiving folate supplementation and support the use of this model for further research on the defective cardiogenesis and hematopoiesis caused by folate deficiencies. Expand
Supplementation with 5-formyltetrahydrofolate alleviates ultraviolet B-inflicted oxidative damage in folate-deficient zebrafish.
- Hung-Chi Tu, Meng-Yun Lin, +4 authors T. Fu
- Chemistry, Medicine
- Ecotoxicology and environmental safety
- 30 October 2019
It is concluded that the intrinsic folate status correlates with the vulnerability to UVB-induced damage in zebrafish larvae, and 5-CHO-THF surpassed both folic acid and NAC in preventingUVB-inflicted oxidative stress and injury in the current experimental zebra fish model. Expand