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OBJECTIVES Alzheimer's disease (AD), frontotemporal dementia (FTD) and vascular dementia (VaD) are the three most common causes of young onset dementias. Most neuroimaging studies of these disorders have involved comparisons with normal controls. The aims of this study were to examine the clinical diagnostic value of magnetic resonance imaging (MRI) and(More)
The purpose of this study was to examine the possible association between "classic" motor neuron disease (cMND) and frontotemporal dementia (FTD), using neuropsychological evaluation and single photon emission computed tomography (SPECT). Psychological tests assessing language, perceptuospatial, memory, and "frontal lobe" functions were given to patients(More)
Objectives—To provide the clinician with a guide to the clinical utility of 99m Tc-HMPAO single photon emission computed tomography (SPECT) and to the interpretation of specific test results in the diVerential diagnosis of dementia. Methods—Three hundred and sixty three patients with dementia were studied prospectively for a median three (range 1–6) years(More)
Chronic renal failure is associated with an increased rate of premature death from cardiovascular disease. Non-invasive identification of asymptomatic cardiac disease should be valuable in the management of such patients, and in selection for transplantation. One hundred and three high-risk patients (66 male, 37 female) with chronic renal failure who were(More)
The clinical, urographic and radionuclide examinations of 28 consecutive patients with incomplete duplication of the upper urinary tract are presented. Four possible types of urodynamic abnormality can occur in this condition and 3 of these were found in 8 of the 28 patients. The urodynamics of normal and duplex upper tracts are reviewed and the question of(More)
Sixteen patients with progressive language disorder have been studied longitudinally. Anomia was a prominent presenting characteristic and mutism ultimately occurred. Patients, however, were clinically heterogeneous. Some exhibited nonfluent, agrammatic features, whereas others demonstrated a fluent aphasia, with profound loss of word meaning. Although(More)
Single photon emission tomographic imaging of the brain using 99mTc HM-PAO was carried out in patients with a clinical diagnosis of Alzheimer's disease, non-Alzheimer frontal-lobe dementia, and progressive supranuclear palsy. Independent assessment of reductions in uptake revealed posterior hemisphere abnormalities in the majority of the Alzheimer group,(More)
OBJECTIVES To provide the clinician with a guide to the clinical utility of 99mTc-HMPAO single photon emission computed tomography (SPECT) and to the interpretation of specific test results in the differential diagnosis of dementia. METHODS Three hundred and sixty three patients with dementia were studied prospectively for a median three (range 1-6) years(More)
A trial of the value of diuresis renography in equivocal upper urinary tract obstruction is presented. Fifty-two patients were examined by standard renography and renography under a diuretic provocation. The results indicate that the technique is of considerable value in making the vital distinction between dilatation on the excretion urogram due to(More)
Two studies were carried out in which 27 and 23 patients respectively with renal space-occupying lesions were assessed by different techniques and the results compared. Instead of proceeding to renal arteriography after the lesion had been found on urography, radionuclide and ultrasound scanning were used in the first study to clarify the nature of the(More)