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The human immunodeficiency virus type I is strongly regulated at the transcriptional level through the interaction of an 86-amino acid protein (Tat) with a viral messenger RNA transcript. Accordingly, the binding of this protein and other cellular factors to the RNA has constituted a significant target for the development of anti-HIV drugs. In the present(More)
Nucleic acid has been attached to the electrodes of thickness-shear-mode acoustic wave devices to produce a biosensor for platinum-based drugs. The decreases in series resonant frequency for interactions of DNA with both cis- and transplatin are indicative of two distinct kinetic processes. The results of a kinetic analysis are interpreted in terms of(More)
An ab initio multiconfigurational (CASPT2//CASSCF) approach has been employed to map radiative and nonradiative relaxation pathways for a cyclam-methylbenzimidazole fluorescent sensor and its metal ion (Zn(2+), Cd(2+), and Cu(2+)) complexes to provide an universal understanding of ON-OFF fluorescent mechanisms for the selective identification of these metal(More)
Heterogeneous catalysis is one of the most important processes in the petroleum and the chemical industries. To be able to screen catalysts at high throughput will dramatically improve performance and reduce costs. Here we used laser-induced fluorescence imaging as a high-throughput screening technique in the combinatorial discovery of active catalysts for(More)
The adsorption of the proteins, bovine serum albumin, fibrinogen, avidin and neutravidin (non-glycosylated form of avidin) to a variety of surfaces imposed on thickness shear mode sensors in examined in a flow-injection analysis format. In all cases, adsorption of these moieties was essentially irreversible, although the magnitude of adsorption was(More)
Paramagnetic metals are frequently used to regulate fluorescence emissions in chemical and biological probes. Accurate quantum calculations offer the first regulation theory that quenching is through the competitive nonradiative decay of the mixed fluorophore/metal (3)ππ*/dd state isoenergetic to the fluorophore-localized (1)ππ* state.
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