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Online social networks (OSNs) have become one of the most effective channels for marketing and advertising. Since users are often influenced by their friends, "word-of-mouth" exchanges, so-called viral marketing, in social networks can be used to increase product adoption or widely spread content over the network. The common perception of viral marketing(More)
Memory impairment progressing to dementia is the main clinical symptom of Alzheimer's disease (AD). Deposition of the amyloid-beta peptide (Abeta) in brain, particularly its 42-amino acid isoform (Abeta42), has been shown to play a primary and crucial role in the pathogenesis of AD. In this study we have developed a recombinant adeno-associated virus (AAV)(More)
Online social networks (OSNs) provide a new platform for product promotion and advertisement. Influence maximization problem arisen in viral marketing has received a lot of attentions recently. Most of the existing diffusion models rely on one fundamental assumption that an influenced user necessarily adopts the product and encourages his/her friends to(More)
Granulocyte colony-stimulating factor (G-CSF) mediates "emergency" granulopoiesis during infection, a process that is mimicked by clinical G-CSF use, yet we understand little about the intracellular signaling cascades that control demand-driven neutrophil production. Using a murine model with conditional deletion of signal transducer and activator of(More)
Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA(More)
BACKGROUND Patient race in the Department of Veterans Affairs (VA) information system was previously recorded based on an administrative or clinical employee's observation. Since 2003, the VA started to collect self-reported race in compliance with a new federal guideline. We investigated the implications of this transition for using race/ethnicity data in(More)
Online social networks have become an imperative channel for extremely fast information propagation and influence. Thus, the problem of finding a minimum number of seed users who can eventually influence as many users in the network as possible has become one of the central research topics recently. Unfortunately, most of related works have only focused on(More)
High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibitor INK128 showed inhibitory effects on both(More)
The least cost influence (LCI) problem, which asks to identify a minimum number of seed users who can eventually influence a large number of users, has become one of the central research topics recently in online social networks (OSNs). However, existing works mostly focused on a single network while users nowadays often join several OSNs. Thus, it is(More)