Huiyuan Zhang

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Online social networks (OSNs) have become one of the most effective channels for marketing and advertising. Since users are often influenced by their friends, "word-of-mouth" exchanges, so-called viral marketing, in social networks can be used to increase product adoption or widely spread content over the network. The common perception of viral marketing(More)
Online social networks have become an imperative channel for extremely fast information propagation and influence. Thus, the problem of finding a minimum number of seed users who can eventually influence as many users in the network as possible has become one of the central research topics recently. Unfortunately, most of related works have only focused on(More)
—Online social networks (OSNs) provide a new platform for product promotion and advertisement. Influence maximization problem arisen in viral marketing has received a lot of attentions recently. Most of the existing diffusion models rely on one fundamental assumption that an influenced user necessarily adopts the product and encourages his/her friends to(More)
BACKGROUND Patient race in the Department of Veterans Affairs (VA) information system was previously recorded based on an administrative or clinical employee's observation. Since 2003, the VA started to collect self-reported race in compliance with a new federal guideline. We investigated the implications of this transition for using race/ethnicity data in(More)
—The least cost influence (LCI) problem, which asks to identify a minimum number of seed users who can eventually influence a large number of users, has become one of the central research topics recently in online social networks (OSNs). However, existing works mostly focused on a single network while users nowadays often join several OSNs. Thus, it is(More)
High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibitor INK128 showed inhibitory effects on both(More)
Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA(More)
Magnetosomes are membrane-enclosed magnetite nanocrystals synthesized by magnetotactic bacteria (MTB). They display chemical purity, narrow size ranges, and species-specific crystal morphologies. Specific transmembrane proteins are sorted to the magnetosome membrane (MM). MamC is the most abundant MM protein of Magnetospirillum gryphiswaldense strain MSR-1.(More)
Doxorubicin (Dox, Adriamycin) has been widely used in breast cancer treatment. But its severe cardio-toxic side effects limited the clinical use. Dox treatment can induce DNA damage and other accompanying effects in cancer cells, and subsequently activates nuclear factor κB (NF-κB) pathway which has a strong pro-survival role in different types of(More)