Huixin Guo

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OBJECT Tuberculosis (TB) continues to be one of the most serious infectious diseases in the world, however, no effective biomarkers can be used for rapid screening of latent tuberculosis infection (LTBI) and active TB. In this study, serum cytokines were screened and tested as potential biomarker for TB diagnosis. METHOD Cytokine array was used to track(More)
To overcome the undesirable side-effects of metronidazole (MTZ), ethylene glycol dimethacrylate is used as the cross-linker, and a series of poly(methacrylic acid) (PMAA) nanogels were prepared to load the MTZ. We investigated the morphology, size, in vitro release property in the simulated gastrointestinal medium, long-term antibacterial performance(More)
BACKGROUND Tuberculosis (TB) is one of the most serious infectious diseases globally and has high mortality rates. A variety of diagnostic tests are available, yet none are wholly reliable. Serum cytokines, although significantly and frequently induced by different diseases and thus good biomarkers for disease diagnosis and prognosis, are not sufficiently(More)
The method of reliability estimation with hybrid uncertainties including random and fuzzy variables is proposed. By means of random set theory, random variables and fuzzy variables are transformed into random set, and then a unified model of reliability is proposed in the unified framework of random set theory. The limit-state function of a structure with(More)
A method of reliability-based design optimization is presented. Uncertainties such random variable and fuzzy variable are remodeled as the formulism of evidence theory. By means of the combination of evidence, the upper and lower bounds of reliability are obtained, and then a substituting model of constraint conditions of reliability is proposed based on(More)
To overcome the undesirable side effects and reduce the cytotoxicity of isoniazid (INH) and rifampin (RMP) in the digestive tract, a poly(methacrylic acid) (PMAA) nanogel was developed as a carrier of INH and RMP. This PMAA/INH/RMP nanogel was prepared as a treatment for intestinal tuberculosis caused by multidrug-resistant Mycobacterium tuberculosis (MTB).(More)
OBJECTIVE To study the dynamic changes of tuberculosis related cytokines among patients during the different courses of treatment, and to analyze their influences on the development and prognoses of tuberculosis. METHODS All patients with active tuberculosis were enrolled from Guangzhou, Shenzhen and Foshan TB control institutes. There were a total of 68(More)
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