• Publications
  • Influence
Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression.
TLDR
Sequence analysis revealed that P15RS cDNA encoded a 312-amino-acid peptide containing a RAR domain that is involved in regulation of nuclear pre-mRNA, which suggests that P 15RS may be a nuclear regulation protein. Expand
p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction*
TLDR
It is demonstrated that inhibition of Wnt signaling by p15RS leads to decreased expression of CYCLIN D1 and c-MYC, two Wnt targeted genes critical for cell growth. Expand
cis-Acting Elements and trans-Acting Factors in the Transcriptional Regulation of Raf Kinase Inhibitory Protein Expression
TLDR
The results obtained with HeLa cells supported the idea that Sp1 and CREB play positive roles in the regulation of RKIP transcription, and suggest that regulators of the expression or activity of Sp1, CREB, and p300 are involved in regulating RKip transcription. Expand
Mitotic cell death in BEL-7402 cells induced by enediyne antibiotic lidamycin is associated with centrosome overduplication.
TLDR
Mitotic cell death and senescence can be induced by treatment of BEL-7402 cells with a low concentration of lidamycin, and centrosome dysregulation may play a critical role in mitotic failure and ultimate cell death following exposure to intermediate dose of lidamcin. Expand
Cellular and molecular evidence for malignancy-inhibitory functions of p15RS
TLDR
It is indicated that p15RS has malignancy inhibitory functions independent of cell cycle inhibition and provide novel insights on the role of p15 in tumor inhibition. Expand
Construction and primary analysis of human keratinocyte model expressing anti-sense protein kinase Cζ
TLDR
The human keratinocyte model expressing anti-sense PKCζ is established successfully, the growth properties of the cell model is analyzed by the detection of cell growth curve and cell cycle phase and the mechanism of the relationship between PKC ζ and CyclinD1 is investigated by the western blotting analysis of CyclinLl protein. Expand
Up-regulation of activities of mitogen-activated protein kinase in psoriatic lesions.
Expression of Smad2 and Smad4 in rhesus monkey endometrium during the menstrual cycle and early pregnancy
TLDR
The data suggest that the epithelium is the major compartment where TGF-βs/activins exert their biological effects via Smads via Smad2 and Smad4 using in situ hybridization. Expand
P15—A new tumor suppressor gene
TLDR
Investigations onp15 in cell differentiation suggest that increased p15 is related to the change of malignant phenotype and the research on the molecular mechanism of p15 in regulation of cell proliferation shows that p15 can inhibit the growth of some kinds of tumor cells, andp15 is the mediator of TGF-β-induced cell arrest. Expand
Effect of PKC pathway on G1/S progression control in HeLa cells
The effect of PKC activity on G1/S progression in HeLa cells has been studied. The result shows that (i) PKC activity alteration in G1 phase affects G1/S progression in HeLa cells. It has beenExpand
...
1
2
...