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  • Yohei Shimono, Maider Zabala, Robert W. Cho, Neethan Lobo, Piero Dalerba, Dalong Qian +9 others
  • 2009
Human breast tumors contain a breast cancer stem cell (BCSC) population with properties reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed between human BCSCs and nontumorigenic cancer cells. Three clusters, miR-200c-141, miR-200b-200a-429, and miR-183-96-182 were downregulated in human BCSCs, normal human and murine(More)
Most cancer patients die as a result of metastasis, thus it is important to understand the molecular mechanisms of dissemination, including intra- and extravasation. Although the mechanisms of extravasation have been vastly studied in vitro and in vivo, the process of intravasation is still unclear. Furthermore, how cells in the tumor microenvironment(More)
Landuse change in metropolitan areas is largely focused on the dynamic nature of urban landuse change. In this research, a spatial statistical model was used to support decision-making with regard to urban growth predictions in the urban fringe of Beijing, China. The model adopted in this study was based on the integration of remote sensing, geographical(More)
Oligometastasis is a clinically distinct subset of metastasis characterized by a limited number of metastases potentially curable with localized therapies. We analyzed pathways targeted by microRNAs over-expressed in clinical oligometastasis samples and identified suppression of cellular adhesion, invasion, and motility pathways in association with the(More)
s u m m a r y This paper presents a modeling approach to simulate runoff and soil erosion at the small watersheds of the Three-Gorge Reservoir drainage area in China by using limited plot data on runoff-soil erosion. The approach coupled the empirical relationships between soil loss and runoff. This relationship is derived from the experimental plots under(More)
Entity matching that aims at finding some records belonging to the same real-world objects has been studied for decades. In order to avoid verifying every pair of records in a massive data set, a common method, known as the blocking-based method, tends to select a small proportion of record pairs for verification with a far lower cost than O(n 2), where n(More)
Keywords: Multi-temporal segmentation Land cover changed object Change indicators Segmentation scale Chi-square transformation a b s t r a c t Land cover change information is crucial to analyse the process and the change patterns of environments and ecological systems. Recent studies have incorporated object-based image analysis for its ability to generate(More)
To characterize a putative laccase gene, LacMP, of Moniliophthora perniciosa FA553 that had been screened using a genome mining approach, then cloned and expressed in Pichia pastoris. The purified recombinant LacMP was ~57 kDa with a maximum laccase activity of 232 U/l. The optimal pH for oxidation reactions with(More)