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Overexpression of a Maize Transcription Factor ZmPHR1 Improves Shoot Inorganic Phosphate Content and Growth of Arabidopsis under Low-Phosphate Conditions
Overexpression of ZmPHR1 led to the upregulation of multiple genes that regulate metabolism during Pi-starvation, which resulted in an elevation in Pi content in shoots, which suggest that PUE could be improved through the manipulation of the TF Zm PHR1 in maize and possibly in other species under Pi-deficient conditions. Expand
Ski‐related novel protein suppresses the development of diabetic nephropathy by modulating transforming growth factor‐β signaling and microRNA‐21 expression
  • Yuanyuan Wang, L. Liu, +12 authors Bing Guo
  • Biology, Medicine
  • Journal of cellular physiology
  • 1 October 2019
The results indicated that SnoN suppresses the development of DN as well as renal fibrosis by downregulating miR‐21, and therefore represents a novel and promising therapeutic target for DN. Expand
BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation.
  • L. Liu, Yuanyuan Wang, +11 authors Bing Guo
  • Chemistry, Medicine
  • Life sciences
  • 1 December 2019
It is suggested that BMP-7 decreases renal fibrosis in DN by regulating miR-21/Smad7 signaling, providing a theoretical basis for the development of novel and effective therapeutic drugs for DN. Expand
Smad2 and Smad3 play antagonistic roles in high glucose-induced renal tubular fibrosis via the regulation of SnoN.
  • Yuanyuan Wang, Xiaohua Zhang, +10 authors Bing Guo
  • Chemistry, Medicine
  • Experimental and molecular pathology
  • 6 January 2020
It is demonstrated that Smad3 could inhibit SnoN expression and increase ECM deposition in NRK52E cells, to promote high glucose-induced renal tubular fibrosis, and Smad2 could induce SnoNexpression and reduce ECM depositing, to inhibit high fructose corn syrup-induced fibrosis. Expand
TAK1 may promote the development of diabetic nephropathy by reducing the stability of SnoN protein.
The study showed that TAK1 impaired SnoN protein level by decreasing the protein stability of SnoN and enhanced EMT and ECM deposition to promote renal fibrosis during DN. Expand
Downregulation of lncRNA ZFAS1 inhibits the hallmarks of thyroid carcinoma via the regulation of miR-302-3p on cyclin D1
The results demonstrated that lncRNA ZFAS1 expression was upregulated in thyroid carcinoma tissues, TT and SW579 cells, and was associated with the proliferation of these two cell lines, and downregulation ZFas1 reduced migration and invasion. Expand
EI24 alleviates renal interstitial fibrosis through inhibition of epithelial‐mesenchymal transition and fibroblast activation
The data indicated that EI24, a novel anti‐fibrosis regulator, was important in the progression of RIF, and was shown to decrease gradually in the kidneys of mice with unilateral ureteral obstruction and in another fibrosis model induced by diabetic kidney disease. Expand
Effects and the possible mechanism of histone deacetylase inhibitor SAHA on the interstitial fibrosis induced by diabetes
SAHA may restore the protein level of Smad7 by enhancing protein stability, then promote the moderate transduction of TGF-β1/Smads signaling pathway, which reduce the fibrosis of renal tubules in diabetic rats. Expand
SOX7—A novel tumor suppressor
The structure and function of SOX7 is introduced, and the possible mechanisms by which it play the role of tumor suppressive arediscussed, which may be mediated by promoter methylation. Expand
Autophagy-related protein EI24 delays the development of pulmonary fibrosis by promoting autophagy.
It is indicated that EI24 attenuates PF through inhibition of EMT process and ECM production by promoting autophagy and the inhibition of Autophagy by 3-methyladenine limited the role of EI 24 in these processes. Expand