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Interaction of calcineurin with substrates and targeting proteins.
Calcineurin is a calcium activated protein phosphatase with a major role in calcium signaling in diverse cells and organs and clinical importance as the target of the immunosuppressive drugsExpand
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Chemical speciation and human health risk of trace metals in urban street dusts from a metropolitan city, Nanjing, SE China.
The modified BCR (the European Community Bureau of Reference) sequential extraction procedure was applied for partitioning and evaluating the mobility, availability and persistence of trace metalsExpand
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Chemical characterization and source apportionment of PM2.5 aerosols in a megacity of Southeast China
PM2.5 aerosol samples were collected during a haze–fog event in winter, as well as in spring, summer, and fall in 2013 within an urban area (Xianlin) and city center area (Gulou) of Nanjing, aExpand
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Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction.
The protein phosphatase calcineurin recognizes a wide assortment of substrates and controls diverse developmental and physiological pathways in eukaryotic cells. Dephosphorylation of theExpand
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Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling
In hippocampal neurons, the scaffold protein AKAP79 recruits the phosphatase calcineurin to L-type Ca2+ channels and couples Ca2+ influx to activation of calcineurin and of its substrate, theExpand
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Chemical fractionation of arsenic and heavy metals in fine particle matter and its implications for risk assessment: A case study in Nanjing, China
Abstract A four-step sequential extraction procedure was used to study the chemical fractionation of As and heavy metals (Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn) in fine particulate matter (PM2.5)Expand
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Fractionation of airborne particulate-bound elements in haze-fog episode and associated health risks in a megacity of southeast China.
Haze caused by high particulate matter loadings is an important environmental issue. PM2.5 was collected in Nanjing, China, during a severe haze-fog event and clear periods. The particulate-boundExpand
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MiR-124 Suppresses Growth of Human Colorectal Cancer by Inhibiting STAT3
Emerging evidence indicate that microRNAs (miRNAs) may play important roles in cancer. Aberrant expression of miRNAs has been frequently identified in different human malignancies, includingExpand
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Mortality effects assessment of ambient PM2.5 pollution in the 74 leading cities of China.
BACKGROUND Ambient fine particulate matter (PM2.5) pollution is currently a most severe and worrisome environmental problem in China. However, current knowledge of the health effects of thisExpand
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Domain Architecture of the Regulators of Calcineurin (RCANs) and Identification of a Divergent RCAN in Yeast
ABSTRACT Regulators of calcineurin (RCANs) in fungi and mammals have been shown to stimulate and inhibit calcineurin signaling in vivo through direct interactions with the catalytic subunit of theExpand
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