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Neuromolecular responses to social challenge: Common mechanisms across mouse, stickleback fish, and honey bee
TLDR
Support is provided for conserved genetic “toolkits” that are used in independent evolutions of the response to social challenge in diverse taxa by determining whether shared neuromolecular mechanisms could underlie behavioral response to territory intrusion across species spanning a broad phylogenetic range.
Temporal dynamics of neurogenomic plasticity in response to social interactions in male threespined sticklebacks
TLDR
It is shown that the genome dynamically responds to social interactions with multiple waves of transcription associated with distinct molecular functions in the brain of male threespined sticklebacks, a species famous for its behavioral repertoire and evolution.
Transcriptional regulatory dynamics drive coordinated metabolic and neural response to social challenge in mice.
TLDR
Localizing ESRRA binding sites in cortical chromatin, it is shown that this nuclear receptor binds both differentially expressed energy-related and neurodevelopmental TF genes and is expressed in both cell types.
Geometric regulation of histone state directs melanoma reprogramming
TLDR
This work uncovers a relationship between geometric features at perimeter regions of multicellular melanoma aggregates, and reprogramming to a stem cell-like melanoma initiating cell (MIC) through histone marks H3K4Me2 andH3K9Ac and suggests mechanotransduction at the periphery of melanoma tumors may orchestrate the activity of epigenetic modifiers to regulate histone state, cellular plasticity, and tumorigenicity.
Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate
TLDR
It is demonstrated for the first time that Tbx18 is required for the normal development of periductal smooth muscle stromal cells in prostate, particularly in the anterior lobe, with a clear impact on prostate health in adult mice.
Geometric regulation of histone state directs melanoma reprogramming
TLDR
The role of geometric features at the perimeter regions of melanoma aggregates in programming stem cell-like state through histone marks is uncovered and mechanotransduction signaling that regulates epigenetic modifiers to regulate tumorigenicity is uncovered.
An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages.
TLDR
Together these data define the diverse fates of Tbx18+ precursors in prostate-associated tissues for the first time, and identify a highly active TAD controlling the gene's essential function in this tissue.
A Mouse Mutation That Dysregulates Neighboring Galnt17 and Auts2 Genes Is Associated with Phenotypes Related to the Human AUTS2 Syndrome
TLDR
Analyzing mutant cerebellar and hippocampal transcriptomes to explain this pathology, disturbances in pathways related to neuron and synapse maturation, neurotransmitter signaling, and cellular stress are identified, suggesting possible cellular mechanisms.
ZSCAN5B and primate-specific paralogs bind RNA polymerase III genes and extra-TFIIIC (ETC) sites to modulate mitotic progression
TLDR
Together, these data implicate the role of ZSCAN5 genes in regulation of Pol III genes and nearby Pol II loci, ultimately influencing cell cycle progression and differentiation in a variety of tissues.
Correction: Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate
TLDR
This research presents a novel probabilistic procedure that allows for direct measurement of the response of the immune system to earthquake-triggered landsliding.
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