Huili Li

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The basis of the decline in circadian rhythms with aging was addressed by comparing the patterns of three behavioral rhythms in young and old rats with the in vitro rhythm of neuronal activity in the suprachiasmatic nuclei (SCN), the primary circadian pacemaker. In some old rats, rhythms of body temperature, drinking, and activity retained significant 24-h(More)
Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidine (AZA). Gene Set Enrichment Analysis demonstrated(More)
Cyclin-dependent kinase 5 (Cdk5) is a unique member of the Cdk family; its kinase activity requires association with its activator, p35 or p39. p35 is the strongest and best characterized activator. Previous studies showed that p35 is a neuron-specific protein that restricts Cdk5 activity in neurons. However, a high expression level of Cdk5 is found in(More)
We examined the relationship between circadian rhythms of body temperature (CTR) and sleep in adult and old female rats. Body temperature was recorded telemetrically for months and sleep for 24 h in a 12:12-h light-dark cycle at 23 degrees C. Some old rats had robust CTRs (old good), and some had unstable or absent CTRs (old unstable). Old unstable rats had(More)
The present study examined intact and ovariectomized adult rats to assess the effects of removal of sex hormones on body temperature (Tb) and sleep. Subjects were 12 female rats, aged 5-8 mo, half of which were bilaterally ovariectomized (OVX). Sleep or waking and Tb were recorded under a 12:12-h light-dark cycle. There was a strong coupling between level(More)
Acute stressors induce changes in numerous behavioral parameters through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Several important hormones in paraventricular nucleus of the hypothalamus (PVN) play the roles in these stress-induced reactions. Corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) and corticosterone are(More)
Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increase the risk of breast cancer. Little is known, however, about the molecular mechanisms by which continuous, long term exposure to tobacco smoke contributes to breast carcinogenesis because most previous studies have focused on short term treatment(More)
We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic sensing of double-stranded RNA (dsRNA) causing a type I interferon response and apoptosis. Knocking down dsRNA sensors TLR3 and MAVS reduces this response 2-fold and blocking(More)
Rheumatoid arthritis is a chronic inflammatory disease characterized by synovial hyperplasia and progressive joint destruction. The impaired apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) is pivotal in this process. However, the molecular mechanisms responsible for the reduced apoptosis are not fully understood. Both nitric oxide(More)
Mushrooms can be found in forests worldwide and have long been exploited as resources in developed economies because of their important agro-industrial, medicinal and commercial uses. For less developed countries, such as those within the Greater Mekong Subregion, wild harvesting and mushroom cultivation provides a much-needed alternative source of income(More)