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A genome‐wide screen for nicotine dependence susceptibility loci
Genome‐wide model free linkage analysis was conducted for nicotine dependence and tobacco use phenotypes in 607 members of 158 nuclear families consisting of at least two ever smokers (100 or moreExpand
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Human Variome Project: an international collaboration to catalogue human genetic variation.
1Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA 2Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA 3GenomicExpand
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Heritability of plasma sex hormones and hormone binding globulin in adult male twins.
Plasma sex hormone concentrations have been used as biomarkers in epidemiological studies of many conditions including cancer, obesity, bone density, and coronary heart disease. The objective of thisExpand
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Genetics and Drug Use as a Complex Phenotype
Drug use is a complex behavior influenced by multiple biological, family, and sociocultural factors. The concurrent use/misuse of multiple drugs is often seen and drug use also co-occurs with otherExpand
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Gene–gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism
Objectives CYP2A6 is the major enzyme involved in nicotine metabolism, yet large interindividual variations in the rate of nicotine metabolism exist within groups of individuals having the sameExpand
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Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR.
OBJECTIVE To determine the relationship between joint variation in 2 dopaminergic genes and the likelihood of nonsmoking following treatment with bupropion sustained release (SR). DESIGN ThreeExpand
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PharmGKB summary: dopamine receptor D2.
Evolutionary Systems Biology, Artificial Intelligence Center, SRI International, Menlo Park, Departments of Genetics and Bioengineering, Stanford University, Stanford, California, USA CorrespondenceExpand
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ABCB1 Variation and Treatment Response in AIDS Patients: Initial Results of the Henan Cohort
HIV/AIDS has the highest mortality among infectious diseases in China. In ongoing efforts to alleviate this crisis, the national government has placed great emphasis on efforts in Henan provinceExpand
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Analysis of Social and Genetic Factors Influencing Heterosexual Transmission of HIV within Serodiscordant Couples in the Henan Cohort
There is considerable variability between individuals in susceptibility to infection by human immunodeficiency virus (HIV). Many social, clinical and genetic factors are known to contribute to theExpand
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Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation.
This article describes the ongoing collaborative effort of six research teams to operationalize and execute an integrative approach to the study of gene x environment interactions in the developmentExpand
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