Learn More
1. To analyze the polymorphic activities of CYP2C8 and evaluate their impact on drug inhibitory potential, three CYP2C8 allelic variants (CYP2C8.2, CYP2C8.3, and CYP2C8.4), two non-synonymous single nucleotide polymorphic variants (R139K and K399R, carried by CYP2C8.3), and wild-type CYP2C8 (CYP2C8.1) were heterologously expressed in yeast, and their(More)
Digital system designs are the product of valuable effort and know-how. Their embodiments, from software and HDL program down to device-level netlist and mask data, represent carefully guarded intellectual property (IP). Hence, design methodologies based on IP reuse require new mechanisms to protect the rights of IP producers and owners. This paper(More)
When transport in networks follows the shortest paths, the union of all shortest path trees G union or logical sum SPT can be regarded as the "transport overlay network." Overlay networks such as peer-to-peer networks or virtual private networks can be considered as a subgraph of G union or logical sum SPT. The traffic through the network is examined by the(More)
On 26 May 2015, an imported Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in Guangdong Province, China, and found to be closely related to the MERS-CoV strain prevalent in South Korea. The full genome of the ChinaGD01 strain was sequenced and analyzed to investigate the epidemiology and evolution of MERS-CoV circulating in South(More)
BACKGROUND Serum microRNAs may be useful biomarkers for diagnosing human diseases. We investigated serum levels of miR-15a and miR-16 in patients with sepsis and systemic inflammatory response syndrome (SIRS) without infection. METHODS We enrolled 166 sepsis patients, 32 SIRS patients, and 24 normal controls. Serum miR-15a and miR-16 expression levels(More)
Increasingly popular reuse-based design paradigms create a pressing need for authorship enforcement techniques that protect the intellectual property rights of designers. We develop the first intellectual property protection protocols for embedding design <italic>watermarks</italic> at the physical design level. We demonstrate that these protocols are(More)
A network of 32 or 64 connected neural masses, each representing a large population of interacting excitatory and inhibitory neurons and generating an electroencephalography/magnetoencephalography like output signal, was used to demonstrate how an interaction between dynamics and connectivity might explain the emergence of complex network features, in(More)
The decrease of the spectral radius, an important characterizer of network dynamics, by removing links is investigated. The minimization of the spectral radius by removing m links is shown to be an NP-complete problem, which suggests considering heuristic strategies. Several greedy strategies are compared, and several bounds on the decrease of the spectral(More)
The age-related loss of skeletal muscle mass and function (sarcopenia) is a consistent hallmark of ageing. Apoptosis plays an important role in muscle atrophy, and the intent of this study was to specify whether apoptosis is restricted to myofibre nuclei (myonuclei) or occurs in satellite cells or stromal cells of extracellular matrix (ECM). Sarcopenia in(More)
In very deep-submicron VLSI, certain manufacturing steps &amp;mdash notably optical exposure, resist development and etch, chemical vapor deposition and chemical-mechanical polishing (CMP)&mdash have varying effects on device and interconnect features depending on local characteristics of the layout. To make these effects uniform and predictable, the layout(More)