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Glutathione and Glutaredoxin Act as a Backup of Human Thioredoxin Reductase 1 to Reduce Thioredoxin 1 Preventing Cell Death by Aurothioglucose*
Background: TrxR1 is the only known reductant of thioredoxin. Results: The glutaredoxin system showed the capacity of reducing thioredoxin 1. Depletion of both TrxR1 activity and glutathione in cellsExpand
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Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes
The tandem Tudor‐like domain‐containing protein Spindlin1 has been reported to be a meiotic spindle‐associated protein. Here we report that Spindlin1 is not associated with the spindle in mouseExpand
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  • Open Access
Thioredoxin 1 Is Inactivated Due to Oxidation Induced by Peroxiredoxin under Oxidative Stress and Reactivated by the Glutaredoxin System*
Background: The Cys-62/Cys-69 dithiol of Trx1 is predicted to have a profound effect on cell signaling. Results: The Cys-62/Cys-69 dithiol of Trx1 was oxidized by Prx1, and this disulfide was reducedExpand
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Inhibitory effect of green tea extract and (-)-epigallocatechin-3-gallate on mammalian thioredoxin reductase and HeLa cell viability.
Mammalian cytosolic thioredoxin reductase (TrxR1) is an attractive target for developing cancer chemopreventive agents since its inhibition is associated with a reduced growth of cancer cells.Expand
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  • Open Access
Ube2g2–gp78-mediated HERP polyubiquitylation is involved in ER stress recovery
ABSTRACT A large number of studies have focused on how individual organisms respond to a stress condition, but little attention has been paid to the stress recovery process, such as the endoplasmicExpand
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Antinociceptive efficacy of verticinone in murine models of inflammatory pain and paclitaxel induced neuropathic pain.
Verticinone, an isosteroidal alkaloid separated from Bulbus Fritillaria (Chinese name "Bei-mu"), was evaluated for its analgesic activities in murine models of inflammatory and neuropathic pain. ItExpand
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Nrf2–ARE Signaling Acts as Master Pathway for the Cellular Antioxidant Activity of Fisetin
Fisetin, a dietary flavonoid, is reported to have cellular antioxidant activity with an unclear mechanism. In this study, we investigated the effect of fisetin on the nuclear factor, erythroid 2-likeExpand
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  • Open Access
Glutaredoxin 2 reduces both thioredoxin 2 and thioredoxin 1 and protects cells from apoptosis induced by auranofin and 4-hydroxynonenal.
AIMS Mitochondrial thioredoxin (Trx) is critical for defense against oxidative stress-induced cell apoptosis. To date, mitochondrial thioredoxin reductase (TrxR) is the only known enzyme catalyzingExpand
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Plasma glutaredoxin activity in healthy subjects and patients with abnormal glucose levels or overt type 2 diabetes
Oxidative stress induced by hyperglycemia is a key factor in the pathogenesis of diabetes complications. Glutaredoxin 1(Grx1) is a cytosolic redox protein that catalyzes GSH-dependent thiol redoxExpand
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Inhibition of mammalian thioredoxin reductase by black tea and its constituents: implications for anticancer actions.
Black tea is recently reported to have anti-carcinogenic effects through pro-oxidant property, but the underlying mechanisms remain unclear. Mammalian cytosolic thioredoxin reductase (TrxR1) is wellExpand
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