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The proteasome inhibitor bortezomib reverses P-glycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway.
Multi-drug resistance (MDR) is one of the obstacles for leukemia therapy, the major cause is an overexpression of P-glycoprotein (P-gp) leading to increased drug efflux. We investigated the reversionExpand
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Down‐regulation of long non‐coding RNA MALAT1 by RNA interference inhibits proliferation and induces apoptosis in multiple myeloma
Multiple myeloma (MM) is a neoplastic plasma‐cell disorder characterized by abnormal proliferation of monoclonal plasma cells in the bone marrow. Metastasis‐associated lung adenocarcinoma transcriptExpand
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Identification of key genes and construction of microRNA–mRNA regulatory networks in multiple myeloma by integrated multiple GEO datasets using bioinformatics analysis
Multiple myeloma (MM) is a common hematological malignancy. To identify key genes and microRNAs in MM, we downloaded two gene expression profiles (GSE16558 and GSE47552) and two microRNA expressionExpand
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Biofabrication of polyphenols coated Nano palladium and its in-vitro cytotoxicity against human leukemia cell lines (K562).
The biofabrication of palladium nanoparticles (PdNPs) using aqueous leaf extract of Pelargonium graveolens is reported herein. The polyphenols present in the Pelargonium graveolens extract are mainlyExpand
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FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells.
AIMS Multiple myeloma (MM) is the second hematological plasma cell malignany and sensitive to fingolimod (FTY720), a novel immunosuppressant. Previous study shows FTY720-induced apoptosis andExpand
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Contents Vol. 127, 2012
miR-144-3p inhibits the proliferation, migration and angiogenesis of multiple myeloma cells by targeting myocyte enhancer factor 2A
Multiple myelomas (MM) are the second most common haematological malignancy, for which no curative treatments have been reported to date. MicroRNAs (miRNAs or miRs) have recently been shown to beExpand