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High-throughput tissue extraction protocol for NMR- and MS-based metabolomics.
Tissue extraction methods compatible with high-throughput, reproducible nuclear magnetic resonance (NMR) spectroscopy- and mass spectrometry-based metabolomics are optimized using fish liver and an automated Precellys 24 bead-based homogenizer, allowing rapid extraction of multiple samples without carryover. Expand
Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics
Metabolomic analysis of tissue samples can be applied across multiple fields including medicine, toxicology, and environmental sciences. A thorough evaluation of several metabolite extractionExpand
Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics.
Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period, demonstrating that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. Expand
Expression profiles of seven glutathione S-transferase (GST) genes from Venerupis philippinarum exposed to heavy metals and benzo[a]pyrene.
The cloning and molecular characteristics of seven genes of the GST family from Venerupis philippinarum together with mRNA tissue distribution patterns and temporal expression profiles in response to cadmium, copper and benzo[a]pyrene exposures are reported. Expand
Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum.
Findings indicated cinnabar induced disturbance in energy metabolism, amino acid metabolism and gut microflora environment as well as slight injury in liver and kidney, which might indirectly result from cinnABar induced oxidative stress. Expand
International NMR-based environmental metabolomics intercomparison exercise.
It is demonstrated that NMR-based metabolomics can generate data that are sufficiently comparable between laboratories to support its continued evaluation for regulatory environmental studies. Expand
Cloning and characterization of an invertebrate type lysozyme from Venerupis philippinarum.
Results indicated that VpLYZ was involved in the immune response against microbe infection and contributed to the clearance of bacterial pathogens. Expand
Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model.
The signaling pathways mediating the effects of exposure to Cu using a toxicogenomic approach in a fish model support the conserved mechanisms of Cu toxicity from lower vertebrates to mammals, provide novel insights into the deleterious effects of Cu in fish, and further demonstrate the utility of fish as environmental sentinels for chemical impacts on both environmental and human health. Expand
Soil acidification increases metal extractability and bioavailability in old orchard soils of Northeast Jiaodong Peninsula in China.
Because of the increased bioavailability of Cu, Zn, Pb and Cd from field-aged orchard soils, regular monitoring of soil conditions in old orchards and vineyards is recommended, and soil metal guidelines need reevaluation to afford appropriate environmental protection under acidifying conditions. Expand
Responses of Mytilus galloprovincialis to bacterial challenges by metabolomics and proteomics.
It is confirmed that an integration of proteomics and metabolomics could provide an insightful view into the effects of pathogens to the marine mussel M. galloprovincialis. Expand