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Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells
- Yifang Wei, Xiaofeng Lai, +7 authors J. Zhang
- Biology, Medicine
- Breast Cancer Research and Treatment
- 10 July 2014
Recent studies have demonstrated that specific miRNAs, such as miR-221/222, may be responsible for tamoxifen resistance in breast cancer. Secreted miRNAs enclosed in exosomes can act as intercellular… Expand
Chronic inflammation confers to the metabolic reprogramming associated with tumorigenesis of colorectal cancer
ABSTRACT It's well known that microenvironment inflammatory signals could promote cancer development and progression. In colorectal cancer (CRC), chronic inflammation is a major driving mechanism for… Expand
Genetic Deletion of Fbw7 in the mouse intestinal epithelium aggravated dextran sodium sulfate-induced colitis by modulating the inflammatory response of NF-κB pathway.
- Huichen Li, Ye Liang, Xiaofeng Lai, W. Wang, J. Zhang, S. Chen
- Medicine, Biology
- Biochemical and biophysical research…
- 15 April 2018
Fbw7 is a type of E3 ubiquitin ligase that targets various proteins for degradation and has been found to have a high expression level in progenitor cells. Deletion of Fbw7 in the intestine results… Expand
Comparison of albumin-bilirubin grade versus Child-Pugh score in predicting the outcome of transarterial chemoembolization for hepatocellular carcinoma using time-dependent ROC.
Background The Child-Pugh score has been used extensively to assess hepatic function and predict post-treatment outcomes in patients with hepatocellular carcinoma (HCC). Recently, the… Expand
Loss of NDRG2 in liver microenvironment inhibits cancer liver metastasis by regulating tumor associate macrophages polarization
The liver is the predominant metastatic site for several types of malignancies. Tumor-associated macrophages (TAMs) in the liver play crucial roles in the metastasis process. Shifting tumor-promoting… Expand