Hui-shu Chen

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There are few transmission electron microscopic studies on bone marrow biopsies of patients with hematological disease owing to the difficulty of overcoming the artifacts of decalcification. Following the fixation of bone marrow biopsies thoroughly before a mild decalcification procedure, ultrastructural studies were performed on 13 patients with varied(More)
OBJECTIVE To study the clinicopathologic features and differential diagnosis of splenic B-cell marginal zone lymphoma (SMZL) involving bone marrow. METHODS The clinical and pathologic features of 22 patients with SMZL were retrospectively studied. Immunophenotypic analysis was carried out by flow cytometry and immunohistochemistry. Immunoglobulin heavy(More)
OBJECTIVE To study the clinical characteristics and pathogenesis of hematidrosis. METHODS Detailed clinical manifestations and natural history of a patient with hematidrosis were presented. A series of laboratory examinations were performed, and skin pathohistologic features and ultra microscopic structures were observed. RESULTS The episodes of skin(More)
OBJECTIVE To study the bone marrow microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression and their clinical significance in patients with aplastic anemia (AA). METHODS Bone marrow biopsies in 51 newly diagnosed patients with AA were evaluated the MVD and VEGF expression by immunostaining with anti-factor VIII related antigen(More)
OBJECTIVE To identify the clinical and pathological features of blastic plasmacytoid dendritic cell neoplasm (BPDC). METHODS The characteristics of BPDC hematodermic neoplasm were discussed with a report of two new cases and review the literatures. RESULTS Both patients presented with skin nodules and the tumors were CD(4)(+) and CD(56)(+). Lineage(More)
OBJECTIVE To explore the hematopathologic features of T-cell large granular lymphocytic leukemia (T-LGLL). METHODS A retrospective analysis of the clinical presentation, bone marrow morphology, immunophenotyping and T-cell receptor gene rearrangement status were performed in 19 patients with T-LGLL. RESULTS Of 19 patients, the most frequent(More)
OBJECTIVE To explore treatment methods for patients with severe aplastic anemia (SAA) failing in immunosuppressive therapy (IST). METHODS Totally 62 SAA patients failing in IST were treated by integrative medicine (IM). The treatment course was divided into three stages: the critical emergency stage, the improvement stage, and the recovery stage. In the(More)
OBJECTIVE To investigate whether fetal bone marrow stromal cells have hemangioblastic characteristics. METHODS Human fetal bone marrow stromal cells (hfMSCs) were isolated and cultured. Immunophenotypes of hfMSCs were tested by FACS. hfMSCs seeded in the matrigel were induced with vascular endothelial growth factor (VEGF) and basic fibroblast growth(More)
OBJECTIVE To analyse the proportion of hepatitis associated aplastic anemia (HAAA) in severe aplastic anemia (SAA) and its clinical features of HAAA. METHODS All newly diagnosed SAA cases in our department in the recent 5 years were analyzed. A case-control study was undertaken to investigate the differences of clinical and laboratory features between(More)
OBJECTIVE To study the clinicopathologic features of aggressive natural killer cell leukemia (ANKL). METHODS The clinical and pathologic features were analyzed in 10 patients with ANKL. The complete blood count, peripheral blood smears, bone marrow aspirates and bone marrow biopsies were studied. Immunophenotypic analysis was carried out by flow cytometry(More)