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OBJECTIVES The objectives of this study were to prepare and characterize the novel adefovir dipivoxil-saccharin cocrystal and to demonstrate the enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation. METHODS Adefovir dipivoxil-saccharin cocrystal was prepared using a novel solution crystallization approach and scaled up to 30 g(More)
Adefovir dipivoxil (AD) is a bis(pivaloyloxymethyl) prodrug of adefovir with chemical stability problem. It undergoes two degradation pathways including hydrolysis and dimerization during storage. Pharmaceutical cocrystallization exhibits a promising approach to enhance aqueous solubility as well as physicochemical stability. In this study we attempted to(More)
Malotilate (MT) is a hepatoprotective drug administered orally. However, MT was found to be a poorly water-soluble drug with low oral bioavailability. In the present investigation, a novel spray-dried emulsion (SDE) loaded with MT was prepared, and its physicochemical properties were characterized by rheological evaluation, particle size measurement, in(More)
In this paper, a direct adaptive neural control scheme with sliding mode method is presented for a class of switched nonlinear systems which is in the presence of model uncertainties and external disturbances. A sliding mode controller based on RBF neural networks (RBF NNs) which are utilized to approximate unknown functions and uncertain nonlinear terms is(More)
Due to the traditional recognition researches prevalently focusing on HRRP’s amplitudes while almost completely neglecting the phases, this paper attempts to directly prove the discriminant availability of HRRP’s phases via two proposed fusion recognition strategies. The first strategy includes three sub-processes, respectively, based on phase cosine, phase(More)
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