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We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25-35% of common SNP variation in the populations surveyed. The map is estimated to capture untyped common variation with an average maximum r2 of between(More)
With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a(More)
The management of a service parts supply chain is especially challenging in environments characterized by low-demand rates, expensive parts and high service requirements. As a result, an increasing number of manufacturers have begun pursuing a strategy that promotes inventory sharing among the dealers in their distribution network. Hence, there is a need(More)
Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing four periodontal states. Insights into(More)
Based on adaptive rood pattern search (ARPS) algorithm, a new fast and efficient motion estimation algorithm called enhanced adaptive rood pattern search (E-ARPS) is proposed in this paper. Unlike ARPS, the E-ARPS utilizes spatial correlations to predict the initial search centre, then introduces a new initial search based on motion vector(MV) centre-biased(More)
The active form of the Xenopus X-box binding protein 1 (xXBP1) partially synergizes and partially antagonizes with BMP-4 signaling. xXBP1 overexpression inhibits mesoderm differentiation and formation of neural tissues. A functional knockdown promotes differentiation of lateral and dorsal mesoderm but not of ventral mesoderm and of neuroectoderm. We show(More)
Human monkeypox was first recognized outside Africa in 2003 during an outbreak in the USA that was traced to imported monkeypox virus (MPXV)-infected West African rodents. Unlike the smallpox-like disease described in the Democratic Republic of the Congo (DRC; a Congo Basin country), disease in the USA appeared milder. Here, analyses compared clinical,(More)
The newly developed transcription activator-like effector protein (TALE) and clustered regularly interspaced short palindromic repeats/Cas9 transcription factors (TF) offered a powerful and precise approach for modulating gene expression. In this article, we systematically investigated the potential of these new tools in activating the stringently silenced(More)
Keywords: Mobile cloud computing Green computing Dynamic program Energy-aware Cloudlets a b s t r a c t Employing mobile cloud computing (MCC) to enable mobile users to acquire benefits of cloud computing by an environmental friendly method is an efficient strategy for meeting current industrial demands. However, the restrictions of wireless bandwidth and(More)