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This paper investigates the problem of boot-strapping a statistical dialogue manager without access to training data and proposes a new probabilistic agenda-based method for simulating user behaviour. In experiments with a statistical POMDP dialogue system, the simu-lator was realistic enough to successfully test the prototype system and train a dialogue(More)
Voice morphing is a technique for modifying a source speaker's speech to sound as if it was spoken by some designated target speaker. Most of the recent approaches to voice morphing apply a linear transformation to the spectral envelope and pitch scaling to modify the prosody. Whilst these methods are effective, they also introduce artifacts arising from(More)
Partially observable Markov decision processes (POMDPs) provide a principled mathematical framework for modelling the uncertainty inherent in spoken dialog systems. However, conventional POMDPs scale poorly with the size of state and observation space. This paper describes a variation of the classic POMDP called the Hidden Information State (HIS) model in(More)
BACKGROUND The head and neck/oral squamous cell carcinoma (HNOSCC) is a diverse group of cancers, which develop from many different anatomic sites and are associated with different risk factors and genetic characteristics. The oral tongue squamous cell carcinoma (OTSCC) is one of the most common types of HNOSCC. It is significantly more aggressive than(More)
  • Xiqiang Liu, Anxun Wang, Lorenzo Lo Muzio, Antonia Kolokythas, Shihu Sheng, Corrado Rubini +5 others
  • 2010
BACKGROUND Lymph node metastasis is a critical event in the progression of tongue squamous cell carcinoma (TSCC). The identification of biomarkers associated with the metastatic process would provide critical prognostic information to facilitate clinical decision making. Previous studies showed that deregulation of manganese superoxide dismutase (SOD2)(More)
Large-conductance Ca(2+)-activated K(+) (BK) channels regulate synaptic transmission by contributing to the repolarization phase of the action potential that invades the presynaptic terminal. BK channels are prone to activation under pathological conditions, such as brain ischemia and epilepsy. It is unclear if activation of these channels contributes to(More)
BACKGROUND & OBJECTIVES Diagnosis for Mycoplasma pneumoniae usually relies on serological tests. PCR technology has some advantages but also limitations. The optimal selection for these tests still needs discussion. This paper reviews the overall diagnostic accuracy of PCR versus serological assays for diagnosis of M. pneumoniae infections and to identify(More)
— Voice morphing is a technique for modifying a source speaker's speech to sound as if it was spoken by some designated target speaker. The core process in a voice morphing system is the transformation of the spectral envelope of the source speaker to match that of the target speaker and linear transformations estimated from time-aligned parallel training(More)
Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis. Herein, we identified the role of miR-148a in gastric cell proliferation. miR-148a knockdown inhibited cell proliferation in gastric cancer cell lines. Conversely, miR-148a overexpression promoted cell proliferation and cell cycle(More)