Hui Wen Chua

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Circulating tumor cells (CTCs) are cells shed from tumors or metastatic sites and are a potential biomarker for cancer diagnosis, management, and prognostication. The majority of current studies use single or infrequent CTC sampling points. This strategy assumes that changes in CTC number, as well as phenotypic and molecular characteristics, are gradual(More)
BACKGROUND Molecular characterization of circulating tumor cells (CTCs) holds great promise for monitoring metastatic progression and characterizing metastatic disease. However, leukocyte and red blood cell contamination of routinely isolated CTCs makes CTC-specific molecular characterization extremely challenging. METHODS Here we report the use of a(More)
Breast cancer is a frequently diagnosed solid tumor in women worldwide (1 ). MicroRNAs (miRNAs), small noncoding RNAs that regulate protein expression, are potential biomarkers in the diagnosis, prognosis, and prediction of response to treatment in breast cancer (2). We recently reported a paper-based method to extract miRNAs from plasma and circulating(More)
Among patients with colorectal cancer (CRC), KRAS mutations were reported to occur in 30–51 % of all cases. CRC patients with KRAS mutations were reported to be non-responsive to anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MoAb) treatment in many clinical trials. Hence, accurate detection of KRAS mutations would be critical in guiding(More)
INTRODUCTION Bariatric surgery is increasingly recognised as an effective treatment for type 2 diabetes that significantly improves glycaemic control, even achieving remission. This study examined perceptions and concerns of diabetic patients towards bariatric surgery as a treatment option for diabetes. MATERIALS AND METHODS A total of 150 patients were(More)
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