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Modern analytical techniques in metabolomics analysis.
TLDR
The combined use of modern instrumental analytical approaches has unravelled the ideal outcomes in metabolomics, and is beneficial to increase the coverage of detected metabolites that can not be achieved by single-analysis techniques.
Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine.
TLDR
Potential applications of robust metabolomics apporoaches in the area of traditional oriental medicine are summarized, and the key role of metabolomics to resolve special TCM issues is highlighted.
Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry.
TLDR
Biochemical analyses revealed that glycocholic acid expression was up-regulated in urine samples associated with HCC, and its pathway analysis suggested the modulation of multiple vital physiological pathways, including primary bile acid biosynthesis, secondary bile acidsynthesis, metabolic pathways, and bile secretion.
Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS.
TLDR
It is concluded that a rapid and validated method has been developed based on UPLC-MS/MS, which shows high and resolution that is more suitable for identifying the bioactive constituents in plasma after oral administration of Chinese herbal medicines, and provides helpful chemical information for further pharmacology and active mechanism research on the Chinese medical formula.
Power of metabolomics in diagnosis and biomarker discovery of hepatocellular carcinoma
TLDR
This technique‐driven review aims to demystify the metabolomics pathway, while also illustrating the potential of this technique, with recent examples of its application in HCC.
Advancing Drug Discovery and Development from Active Constituents of Yinchenhao Tang, a Famous Traditional Chinese Medicine Formula
TLDR
An overview of the recent and potential developments of chemical fingerprinting coupled with systems biology advancing drug discovery towards more agile development of targeted combination therapies for the YCHT is provided.
Recent and potential developments of biofluid analyses in metabolomics.
TLDR
Emerging as a promising biofocus, metabolomics will drive biofluid analyses and offer great benefits for public health in the long-term, it must be emphasized that these biofluids are complementary.
Urine Metabolomics Analysis for Biomarker Discovery and Detection of Jaundice Syndrome in Patients With Liver Disease*
TLDR
The potential biomarkers from JS disease are found by using a nontarget metabolomics method, and their usefulness in human JS diagnosis is tested and new insight into pathophysiologic mechanisms is provided.
Ultra-performance liquid chromatography coupled to mass spectrometry as a sensitive and powerful technology for metabolomic studies.
TLDR
Hyphenated UPLC/MS technique is becoming a useful tool in the study of body fluids, represents a promising hyphenated microseparation platform in metabolomics and has a strong potential to contribute to disease diagnosis.
Rapid and global detection and characterization of aconitum alkaloids in Yin Chen Si Ni Tang, a traditional Chinese medical formula, by ultra performance liquid chromatography-high resolution mass
TLDR
It is concluded that the screening capability of Metabolynx XS with MDF, together with the utilization of MS(E) in structural elucidation, can facilitate a rapid and comprehensive searching and effective structural characterization of aconitum alkaloids in TCMF.
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