Learn More
We investigated the expression of Ggamma13, a recently discovered G protein subunit, and a selection of Gbeta subunits in retinal bipolar cells, by using a transgenic mouse strain in which green fluorescent protein is strongly expressed in a single type of cone bipolar cell. The cells have ON morphology, and patch-clamp recordings in slices confirmed that(More)
Dot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of histone H3 (H3K79). In Saccharomyces cerevisiae, Dot1-mediated H3K79 methylation is associated with telomere silencing, meiotic checkpoint control, and DNA damage response. The biological function of H3K79 methylation in mammals, however, remains poorly understood. Using(More)
A rat model of depression has been recently developed by exogenous corticosterone administration. In this study, we further determined whether corticosterone administration also increased depression-like behavior in mice and explored the brain biochemical consequences of exposure to this administration paradigm. Mice received repeated injections of vehicle(More)
Chinese input presents unique challenges to the field of human computer interaction. This study provides an anatomical analysis of today's standard Chinese input process, which is based on pinyin, a phonetic spelling system in Roman characters. Through a combination of human performance modeling and experimentation, our study decomposed the Chinese input(More)
[1] Multiple data sets, mostly from satellite observations, are used to evaluate the performance of the Weather Research and Forecasting model with Chemistry (WRF‐Chem) in simulating the distribution and evolution of aerosol, clouds, precipitation and chemistry during the dry season in South America. A 9‐day WRF‐Chem simulation with 36 km horizontal(More)
[1] The radiative effects of upper tropospheric (UT) clouds observed by CloudSat and Aura MLS during June-July-August 2008 are examined and contrasted. We find that the UT cloud occurrence frequency observed by MLS is more than CloudSat by 4 – 10% in the tropical average and by 40$60% near the tropopause in the deep convective regions. The clouds detected(More)
Differential DNA methylation of the paternal and maternal alleles regulates the parental origin-specific expression of imprinted genes in mammals. The methylation imprints are established in male and female germ cells during gametogenesis, and the de novo DNA methyltransferase DNMT3A and its cofactor DNMT3L are required in this process. However, the(More)
of multimodal systems from the ground up (see articles by Cohen and McGee and Pieraccini et al. in this section). This article discusses six main categories of guidelines and represents a preliminary effort to establish principles for multimodal interaction design. A more detailed discussion of these guidelines will be available in [6]. Requirements(More)
AIMS Ischemic preconditioning (IPC) is a potent form of endogenous protection. However, IPC-induced cardioprotective effect is significantly blunted in insulin resistance-related diseases and the underlying mechanism is unclear. This study aimed to determine the role of glucose metabolism in IPC-reduced reperfusion injury. METHODS Normal or streptozotocin(More)
Chronic corticosterone injections induce hippocampus tissue damage and depression-like behavior in rodent animals, the cause of which is not known. Nevertheless, increasing evidence shows that adenylate kinase (AK) and AMP-activated protein kinase (AMPK) play a very important role in intracellular energy metabolism and are especially critical for neurons(More)