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Mobile sinks are needed in many sensor network applications for efficient data collection, data querying, localized sensor reprogramming, identifying and revoking compromised sensors, and other network maintenance. Employing mobile sinks however raises a new security challenge: if a mobile sink is given too many privileges, it will become very attractive(More)
To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected(More)
Antimicrobial peptides (AMPs) represent a class of natural peptides that form a part of the innate immune system, and this kind of 'nature's antibiotics' is quite promising for solving the problem of increasing antibiotic resistance. In view of this, it is highly desired to develop an effective computational method for accurately predicting novel AMPs(More)
Node compromise is a serious security threat that hinders the successful deployment of large-scale wireless sensor networks. A node compromise often consists of three stages: physically obtaining and compromising the sensors, redeploying the compromised sensors, and compromised nodes launching attacks after their rejoining the network. By far, all the(More)
This study focused on the screening of small-molecule inhibitors that target signal transducers and activators of transcription 3 (Stat3) in human breast carcinoma. The constitutive activation of Stat3 is frequently detected in human breast cancer cell lines as well as clinical breast cancer specimens and may play an important role in the oncogenesis of(More)
Autophagy is a conserved degradative pathway that is induced in response to various stress and developmental conditions in eukaryotic cells. It allows the elimination of cytosolic proteins and organelles in the lysosome/vacuole. In the yeast Saccharomyces cerevisiae, the integral membrane protein Atg9 (autophagy-related protein 9) cycles between(More)
The existing time synchronization schemes in sensor networks were not designed with security in mind, thus leaving them vulnerable to security attacks. In this paper, we first identify various attacks that are effective to several representative time synchronization schemes, and then focus on a specific type of attack called delay attack, which cannot be(More)
Today vehicle theft rate is very high, thus tracking/alarming systems are being deployed with an increasingly popularity. These systems however bear some limitations such as high cost, high false-alarm rate, and easy to be disabled. This paper describes the design, implementation and evaluation of a Sensor-network-based Vehicle Anti-Theft System (SVATS) to(More)
Autophagy is a major intracellular degradative pathway that is involved in various human diseases. The role of autophagy, however, is complex; although the process is generally considered to be cytoprotective, it can also contribute to cellular dysfunction and disease progression. Much progress has been made in our understanding of autophagy, aided in large(More)
NLRP3 inflammasome is a multi-protein complex, which plays crucial roles in host defense against pathogens. The NLRP3 protein level is considered rate limiting for the activation of the inflammasome, thus its expression must be tightly controlled to maintain immune homeostasis. However, the molecular mechanisms that modulate NLRP3 expression, especially at(More)