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Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus
TLDR
This study indicates that inhibiting P2X7Rs protects against transient global cerebral I/R injury by reducing the I-R-induced inflammatory response, which suggests inhibition of P2x7Rs may be a promising therapeutic strategy for clinical treatment of transient global brain injury. Expand
Sneddon’s syndrome: a comprehensive review of the literature
TLDR
The optimal management remains an unsolved problem and long-term anticoagulation have been recommended for cerebral ischemic events based on the presumed pathogenesis, and there are controversial results in treatment of SS with immunomodulatory agents. Expand
Reversible cerebral vasoconstriction syndrome following red blood cells transfusion: a case series of 7 patients
TLDR
Reversible cerebral vasoconstriction syndrome is a rare complication as a result of blood transfusion in patients with chronic severe anemia and should be considered in patients who show severe headache or neurologic deficits after transfusion. Expand
Transient Mydriasis and Branch Retinal Artery Occlusion Following Carotid Angioplasty and Stenting
A case is described of serial ophthalmic sequelae of carotid angioplasty and stenting. The patient developed a transient mydriasis and was later observed to have a branch retinal artery occlusion.
Target inhibition of caspase-8 alleviates brain damage after subarachnoid hemorrhage
TLDR
It is suggested that caspase-8 inhibition alleviates subarachnoid hemorrhage-induced brain injuries by suppressing inflammation. Expand
EGB1212 post-treatment ameliorates hippocampal CA1 neuronal death and memory impairment induced by transient global cerebral ischemia/reperfusion.
TLDR
EGB1212 exerted significant neuroprotection in GCI/R in both preventative and post-treatment settings, and shows great potential for clinical applications. Expand
Extreme delta brush guides to the diagnosis of anti-NMDAR encephalitis
TLDR
EEG may be a readily accessible sign for suspected anti-NMDAR encephalitis, and in both cases, EEG initially revealed the extreme delta brush (EDB) pattern of beta bursting on the peaks and/or the troughs of delta waves, which led to subsequent NMDAR antibody testing and the confirmative diagnosis. Expand
DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage
TLDR
It is demonstrated that the effects of DKK3 against ICH were mediated, at least partly, by the Kremen-1 and DVL-1 pathways, thereby ameliorating the short- and long-term sequelae after ICH. Expand
Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats
TLDR
It is demonstrated that activating TGR5 could reduce BBB breakdown and improve neurological functions through BRCA1/Sirt1 signaling pathway after MCAO, and may serve as a potential new candidate to relieve brain injury after M CAO. Expand
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