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Decomposition is a basic strategy in traditional multiobjective optimization. However, it has not yet been widely used in multiobjective evolutionary optimization. This paper proposes a multiobjective evolutionary algorithm based on decomposition (MOEA/D). It decomposes a multiobjective optimization problem into a number of scalar optimization subproblems(More)
Partly due to lack of test problems, the impact of the Pareto set (PS) shapes on the performance of evolutionary algorithms has not yet attracted much attention. This paper introduces a general class of continuous multiobjective optimization test instances with arbitrary prescribed PS shapes, which could be used for studying the ability of multiobjective(More)
MapReduce programming model has simplified the implementation of many data parallel applications. The simplicity of the programming model and the quality of services provided by many implementations of MapReduce attract a lot of enthusiasm among distributed computing communities. From the years of experience in applying MapReduce to various scientific(More)
The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 transmission and in designing effective vaccines. Here, we developed a mathematical model of random viral evolution and, together with phylogenetic tree construction, used it to(More)
We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3,(More)
While large grids are currently supporting the work of thousands of scientists, very little is known about their actual use. Because of strict organizational permissions, there are few or no traces of grid workloads available to the grid researcher and practitioner. To address this problem, in this work we present the Grid Workloads Archive (GWA), which is(More)
Real-world observable physical and chemical characteristics are increasingly being calculated from the 3D structures of biomolecules. Methods for calculating pK(a) values, binding constants of ligands, and changes in protein stability are readily available, but often the limiting step in computational biology is the conversion of PDB structures into formats(More)
Image registration is concerned with the establishment of correspondence between images of the same scene. One challenging problem in this area is the registration of multispectral/multisensor images. In general, such images have different gray level characteristics, and simple techniques such as those based on area correlations cannot be applied directly.(More)