Learn More
Annual Reviews is a non-profit publisher that offers accurate, enlightened syntheses of the research literature in the natural and social sciences in order to advance knowledge and to provide an informed view to the wider public. The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and(More)
To the Editor: Pulmonary nontuberculous mycobacteria (NTM) diseases share clinical signs with tuberculosis (TB), causing a clinical dilemma with regard to therapy for patients with these diseases (1). In the past 30 years (post-AIDS era), NTM have increasingly been associated with pulmonary diseases in humans (2). Recent studies in urban areas of the(More)
Sirtuins are a class of enzymes originally identified as nicotinamide adenine dinucleotide (NAD)-dependent protein lysine deacetylases. Among the seven mammalian sirtuins, SIRT1-7, only SIRT1-3 possess efficient deacetylase activity in vitro, whereas SIRT4-7 possess very weak in vitro deacetylase activity. Several sirtuins that exhibit weak deacetylase(More)
Dasatinib (BMS-354825) is a FDA-approved multitargeted kinase inhibitor of BCR/ABL and Src kinases. It is now used in the treatment of chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapies, including imatinib. Here we report a novel effect of dasatinib on inducing the differentiation of acute myeloid leukemia (AML) cells(More)
Hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor that mediates the adaptation of tumor cells and tissues to the hypoxic microenvironment, has attracted considerable interest as a potential therapeutic target. Tirapazamine (TPZ), a well-characterized bioreductive anticancer agent, is currently in Phase II and III clinical trials. A(More)
By exploiting recent developments associated with coupled microcavities, we introduce the concept of the PT-symmetric phonon laser with balanced gain and loss. This is accomplished by introducing gain to one of the microcavities such that it balances the passive loss of the other. In the vicinity of the gain-loss balance, a strong nonlinear relation emerges(More)
To estimate the prevalence of extensively drug-resistant tuberculosis (XDR TB) in China, we retrospectively analyzed drug-resistance profiles of 989 clinical Mycobacterium tuberculosis isolates. We found 319 (32.3%) isolates resistant to ≥1 first-line drugs; 107 (10.8%) isolates were multidrug resistant, of which 20 (18.7%) were XDR. XDR TB is of major(More)
Optomechanically-induced transparency (OMIT) and the associated slowing of light provide the basis for storing photons in nanoscale devices. Here we study OMIT in parity-time (PT)-symmetric microresonators with a tunable gain-to-loss ratio. This system features a sideband-reversed, non-amplifying transparency, i.e., an inverted-OMIT. When the gain-to-loss(More)
We investigate the nonlinear interaction between a squeezed cavity mode and a mechanical mode in an optomechanical system (OMS) that allows us to selectively obtain either a radiation-pressure coupling or a parametric-amplification process. The squeezing of the cavity mode can enhance the interaction strength into the single-photon strong-coupling regime,(More)