Learn More
BACKGROUND A wide array of proteins is secreted into the bile and may be associated with biliary tract diseases. We attempted to discover novel biomarker in bile for cholangiocarcinoma. METHODS Bile was collected from patients with bile duct obstruction. Proteins were separated by 2-dimensional electrophoresis and identified by mass spectrometry. Levels(More)
BACKGROUND/OBJECTIVES Elevated concentrations of Hepatocarcinoma-Intestine-Pancreas/Pancreatitis-associated Protein I (HIP/PAP-I) in pancreatic juice have been reported in patients with pancreatic adenocarcinoma and have been considered as a promising tumor marker. This study was conducted to investigate whether biliary HIP/PAP-I can be used in the(More)
We propose a scheme to generate single-cycle powerful terahertz (THz) pulses by ultrashort intense laser pulses obliquely incident on an underdense plasma slab of a few THz wavelengths in thickness. THz waves are radiated from a transient net current driven by the laser ponderomotive force in the plasma slab. Analysis and particle-in-cell simulations show(More)
The acceleration of ions in collisionless electrostatic shocks and solitary waves, driven by ultrashort intense laser pulses in a thin solid target under different conditions, is investigated theoretically. When a shock is formed, ions with certain initial velocities inside the target can be accelerated by the electrostatic field at the shock front to twice(More)
The generation of laser-driven dense relativistic electron layers from ultra-thin foils and their use for coherent Thomson backscattering is discussed, applying analytic theory and one-dimensional particlein-cell simulation. The blow-out regime is explored in which all foil electrons are separated from ions by direct laser action. The electrons follow the(More)
Powerful coherent terahertz (THz) pulses with a broad spectrum (0.1-3 THz) can be produced from a laser-driven wakefield through linear mode conversion in inhomogeneous magnetized plasmas with the maximum plasma density of 10(17) cm(-3). This occurs when a laser pulse, with an optimized duration about 300 fs, is incident either normally or obliquely to the(More)
We investigated numerically the formation and propagation of the electrostatic shocks in overdense plasmas irradiated by intense ultrashort laser pulses. The dependence of the initial shock speeds on the parameters of the plasma and the laser is explained by invoking the modified momentum conservation model. The acceleration of ions by the shocks is also(More)