Hugues Leduc

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OBJECTIVES This study sought to determine the impact of steroid therapy on cardiomyopathy and mortality in patients with Duchenne muscular dystrophy (DMD). BACKGROUND DMD is a debilitating X-linked disease that afflicts as many as 1 in 3,500 boys. Although steroids slow musculoskeletal impairment, the effects on cardiac function and mortality remain(More)
OBJECTIVES This study sought to assess the prognostic value of physical examination in a modern treated heart failure population. BACKGROUND The physical examination is the cornerstone of the evaluation and monitoring of patients with heart failure. Yet, the prognostic value of congestive signs (i.e., peripheral edema, jugular venous distension, a third(More)
INTRODUCTION Optimal cryoballoon ablation parameters for pulmonary vein (PV) isolation remain to be defined. We conducted a randomized preclinical trial to compare 2- versus 4-minute ablation lesions and assess the safety of active (forced) cryoballoon deflation. METHODS AND RESULTS Thirty-two dogs underwent PV isolation with a second-generation 23 mm(More)
BACKGROUND Hypertension is an established risk factor for new-onset atrial fibrillation (AF). However, the relationship between blood pressure and recurrent AF is less well understood. METHODS AND RESULTS A pooled analysis of patient-level data from AFFIRM and AF-CHF trials was conducted on all 2,715 patients with paroxysmal or persistent AF, 68 ± 8(More)
BACKGROUND Aortic coarctation has been associated with generalized vascular disease, yet little is known about retinal vascular patterns and their changes over time. OBJECTIVES The aim of this study is to characterize the nature and extent of retinal vascular disease in adults with aortic coarctation, and explore age-related effects and associations with(More)
BACKGROUND Many adults with repaired tetralogy of Fallot have had prior Blalock-Taussig shunts. These shunts may theoretically hinder growth and development of the ipsilateral arm. METHODS We prospectively enrolled consecutive patients with tetralogy of Fallot in a cross-sectional study to measure arm length and assess handgrip strength. Bilateral(More)
AIMS To investigate the association between baseline systolic blood pressure levels and mortality in patients with AF with or without LV dysfunction. Hypertension leads to cardiovascular disease but, in specific groups, low blood pressure has been associated with a paradoxical increase in mortality. In patients with AF and heart failure, the relationship(More)
INTRODUCTION Rate and rhythm control strategies for atrial fibrillation (AF) are not always effective or well tolerated in patients with congestive heart failure (CHF). We assessed reasons for treatment failure, associated characteristics, and effects on survival. METHODS AND RESULTS A total of 1,376 patients enrolled in the AF-CHF trial were followed for(More)
In this paper, we consider the basic reproduction number, R0, a parameter that characterizes the transmission potential of an epidemic, and explore a novel way for estimating it. We introduce a stochastic process which takes as starting points the classical SIR (susceptibles-infected-removed) models, deterministic and stochastic. The estimation method rests(More)
BACKGROUND The association between standard parameters from a simple 12-lead ECG (i.e., QRS duration and PR, JT, and QT intervals) and adverse cardiovascular outcomes (cardiovascular mortality, all-cause mortality, arrhythmic mortality, and hospitalizations) in patients with a history of atrial fibrillation (AF) has not been previously studied. METHODS(More)