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Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes
- M. Pittà, M. Goldberg, V. Volman, Hugues Berry, E. Ben-Jacob
- BiologyJournal of biological physics
- 12 June 2009
A concise mathematical model for glutamate-induced astrocytic intracellular Ca2 + dynamics that captures the essential biochemical features of the regulatory pathway of inositol 1,4,5-trisphosphate (IP3) and the existence of new putative dynamical features is demonstrated.
Monte carlo simulations of enzyme reactions in two dimensions: fractal kinetics and spatial segregation.
- Hugues Berry
- BiologyBiophysical journal
- 1 October 2002
Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression
A glia–neuron interaction at the perisomatic space of LHb is involved in setting the neuronal firing mode in models of a major psychiatric disease, and Kir4.1 in the LHb might have potential as a target for treating clinical depression.
Nonlinear Gap Junctions Enable Long-Distance Propagation of Pulsating Calcium Waves in Astrocyte Networks
A model of the gap-junctional route for intercellular Ca2+ wave propagation in astrocytes is proposed and it is shown that long-distance regenerative signaling requires nonlinear coupling in the gap junctions, and short-distance Regenerative signaling is favored when the internalCa2+ dynamics implements frequency modulation-encoding oscillations with pulsating dynamics.
Supervised and Evolutionary Learning of Echo State Networks
This paper proposes to apply CMA-ES, the state-of-the-art method in evolutionary continuous parameter optimization, to the evolutionary learning of ESN parameters, and shows that the evolutionary ESN obtain results that are comparable with those of the best topology-learning methods.
Localization of Protein Aggregation in Escherichia coli Is Governed by Diffusion and Nucleoid Macromolecular Crowding Effect
3D individual-based modeling is used to show that these three ingredients are sufficient and necessary to reproduce the available experimental data on aggregate localization in the cells and strongly support the hypothesis that the localization of aging-related protein aggregates in the poles of E. coli results from the coupling of passive diffusion-aggregation with spatially non-homogeneous macromolecular crowding.
Sparse short-distance connections enhance calcium wave propagation in a 3D model of astrocyte networks
- Jules Lallouette, M. Pittà, E. Ben-Jacob, Hugues Berry
- Biology, PhysicsFront. Comput. Neurosci.
- 16 April 2014
Computer simulations of the model suggest that changing the topology of the network is indeed sufficient to reproduce the distinct ranges of ICW propagation reported experimentally, and provide support to recent experimental findings that point toward a significant functional role of the organization of gap-junction couplings into proper astroglial networks.
Endocannabinoids mediate bidirectional striatal spike‐timing‐dependent plasticity
The existence of rapid responsiveness of synaptic plasticity at corticostriatal synapses in a major synaptic learning rule, spike‐timing‐dependent plasticity (STDP), is explored and it is found that spike‐ Timing‐ dependent depression (tLTD) progressively disappears when the number of paired stimulations is decreased.
A Tale of Two Stories: Astrocyte Regulation of Synaptic Depression and Facilitation
This model explains several experimental observations yet unsolved, and uncovers astrocytic gliotransmission as a possible transient switch between short-term paired-pulse depression and facilitation, which has deep implications on the processing of neuronal spikes and resulting information transfer at synapses.
Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity
- M. Pittà, V. Volman, Hugues Berry, V. Parpura, A. Volterra, E. Ben-Jacob
- BiologyFront. Comput. Neurosci.
- 28 May 2012
The possibility that astrocytes perform genuine information processing by means of their calcium signaling and are players in the physiological setting of the basal tone of synaptic transmission is considered, supported by experimental evidence.