Hugo Vicentin Alves

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Chagas disease, which is caused by the flagellate parasite Trypanosoma cruzi, affects 8-10 million people in Latin America. The disease is endemic and is characterised by acute and chronic phases that develop in the indeterminate, cardiac, and/or gastrointestinal forms. The immune response during human T. cruzi infection is not completely understood,(More)
BACKGROUND The objective of this study was to investigate the association between KIR genes and the immunopathogenesis of leprosy. METHODS The types of KIR and HLA genes were evaluated by PCR-SSOP-Luminex in 408 patients with leprosy and 413 healthy individuals. Statistical analysis was performed using the Chi-square or Fisher's exact test and stepwise(More)
Many genes including HLA, KIR, and MICA genes, as well as polymorphisms in cytokines have been investigated for their role in infectious disease. HLA alleles may influence not only susceptibility or resistance to leprosy, but also the course of the disease. Some combinations of HLA and KIR may result in negative as well as positive interactions between NK(More)
Leprosy is a chronic infectious disease caused by an obligate intracellular bacterium known as Mycobacterium leprae. Exposure to the bacillus is necessary, but this alone does not mean an individual will develop clinical symptoms of the disease. In recent years, several genes have been associated with leprosy and the innate immune response pathways converge(More)
Dengue infection (DI) transmitted by arthropod vectors is the viral disease with the highest incidence throughout the world, an estimated 300 million cases per year. In addition to environmental factors, genetic factors may also influence the manifestation of the disease; as even in endemic areas, only a small proportion of people develop the most serious(More)
BACKGROUND The reason for the difference in susceptibility to red blood cell (RBC) alloimmunization among patients with sickle cell disease (SCD) is not clearly understood and is probably the result of multiple factors. Our hypothesis is that genetic polymorphisms are associated with RBC alloimmunization. STUDY DESIGN AND METHODS We investigated the(More)
Luciana R Jarduli (lucianajarduli@gmail.com) Hugo V Alves (hugovicentin@gmail.com) Fabiana C Souza (fsouza@ilsl.br) Elaine V C Marcos (emarcos@ilsl.br) Ana C Pereira (anacarlap@gmail.com) Ida M F Dias-Baptista (ifoschiani@gmail.com) Vinícius M Fava (vinifava@hotmail.com) Marcelo T Mira (m.mira@pucpr.br) Milton O Moraes (mmoraes@fiocruz.br) Marcos C L(More)
BACKGROUND Polycystic ovary syndrome (PCOS) is the endocrinopathy that affects women in their reproductive age. The physiopathology involves multifactorial mechanisms, including cytokine gene regulation. METHODS The review was conducted in the database PubMed, with articles published between 2005 and 2015. The selected studies evaluated the(More)
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