Hugo Morales-Ballejo

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OBJECTIVES This study sought to evaluate the efficacy and safety of fasudil, an orally available rho kinase inhibitor, in patients with stable angina. BACKGROUND Several small, non-placebo-controlled trials suggest that fasudil reduces myocardial ischemia in patients with stable or vasospastic angina. METHODS In a multicenter, double-blind,(More)
OBJECTIVES This study prospectively evaluated whether transdermal nitroglycerin patches could limit the extent of exercise-induced left ventricular ischemia as assessed by quantitative thallium-201 tomography. BACKGROUND Although antianginal medications are effective at reducing chest pain symptoms in patients with coronary artery disease, there is(More)
BACKGROUND Nitrates are widely used in the treatment of angina in patients with acute myocardial infarction (AMI). Short-term administration prevents left ventricular (LV) dilation and infarct expansion. However, little information is available regarding their long-term effects on LV remodeling in patients surviving Q-wave AMI. METHODS AND RESULTS This(More)
This study describes correlations between the mean daily blood pressures determined by ambulatory blood pressure monitoring and those obtained during psychophysiologic stress testing. Seven normotensive and 21 hypertensive persons were monitored for hemodynamic changes in the laboratory while undergoing various standardized, low-challenge psychophysiologic(More)
A study of septal Q wave response in lead CM5 was carried out to evaluate its usefulness in predicting coronary artery disease. Q wave amplitude was measured in 50 patients with coronary artery disease and 50 normal subjects before and immediately after exercise. In the 100 patients evaluated with coronary angiography, the septal Q wave in lead, CM5 was(More)
The change in the R wave and the response of the ejection fraction to upright bicycle stress testing with radionuclide angiographic studies were determined for 18 control subjects and 29 patients with coronary arterial disease (70 percent stenosis or more). In the control group, all had an increase in the ejection fraction from 64.8 +/- 7.7 to 75.7 +/- 9.4(More)
Nitrates are widely used in the treatment of patients with ischemic heart disease and in those with angina following acute myocardial infarction. Short-term studies indicate that the administration of nitrates may prevent left ventricular (LV) dilation and infarct expansion. Animal models suggest that prolonged nitroglycerin use after infarction may limit(More)
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