Hugo Miranda

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Distributed applications are becoming increasingly complex, often requiring the simultaneous use of several communication channels with different qualitiesof-service. This paper presents the Appia system, a protocol kernel that supports applications requiring multiple coordinated channels. Appia offers a clean and elegant way for the application to express(More)
GlobData is a project that aims to design and implement a middleware tool offering the abstraction of a global object database repository. This tool, called Copla, supports transactional access to geographically distributed persistent objects independent of their location. Additionally, it supports replication of data according to different consistency(More)
The mechanism of action of tramadol includes the activation of opioid receptors, and the potential ability of the drug to induce tolerance and physical dependence has been evaluated in different animal species and humans. This work was designed to study the involvement of opioid receptors in the antinociceptive activity and the potential ability to develop(More)
The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected as a model of acute visceral pain. Isobolograms were constructed to assess the interactions of clonidine and each nonsteroidal(More)
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, paracetamol and piroxicam induced dose-dependent antinociception in mice tested with the acetic acid writhing test. The isobolographic analysis of the simultaneous intraperitoneal administration of fractions of the ED50's of morphine with each nonsteroidal(More)
GLOBDATA is a project that aims to design and implement a middleware tool offering the abstraction of a global object database repository. This tool, called COPLA, supports transactional access to geographically distributed persistent objects independent of their location. Additionally, it supports replication of data according to different consistency(More)
Vehicular ad hoc networks present challenging characteristics, such as very dynamic behavior and sparse connectivity, that need to be taken into account in designing adequate communication support. Gossip-based protocols have recently emerged as an effective approach to providing reliable and efficient communication in this domain. Nonetheless, despite the(More)
OBJECTIVES Aristotelia chilensis leaves (Elaeocarpaceae) are used in Chilean folk medicine to treat pain and inflammation. A bioguided study was carried out on serial extracts (hexane, dichloromethane, methanol, aqueous extract (INFU) and a crude mixture of alkaloids (ALK-MIX). All extracts were evaluated for (1) topical administration against both(More)
The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdominal constriction test of mice(More)