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Metabolic enzymes are involved in the activation/deactivation of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyiridine (MPTP) neurotoxin and its naturally occurring analogs 2-methyltetrahydro-β-carbolines. The metabolic profile and biotransformation of these protoxins by three enzymes, monoamine oxidase (MAO), cytochrome P450, and heme peroxidases(More)
—The development of new technologies for the design of DNA microarrays has boosted the generation of large volumes of biological data, which requires the development of efficient computational methods for their analysis and annotation. On these sets of data, the biclusters construction algorithms attempt to identify coherent associations of genes and(More)
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