Hugh S. Taylor

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Implantation failure: molecular mechanisms and clinical treatment

Hakan Cakmak, Hugh S. Taylor
Human reproduction update
2011

BACKGROUND Implantation is a complex initial step in the establishment of a successful pregnancy. Although embryo quality is an important determinant of implantation, temporally coordinated… (More)

HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.

Hugh S. Taylor, Aydin Arici, David L. Olive, Peter Igarashi
The Journal of clinical investigation
1998

Hox genes are well-known transcriptional regulators that play an essential role in directing embryonic development. Mice that are homozygous for a targeted disruption of the Hoxa10 gene exhibit… (More)

Contribution of bone marrow-derived stem cells to endometrium and endometriosis.

Hongling Du, Hugh S. Taylor
Stem cells
2007

Bone marrow-derived cells (BMDCs) can differentiate into nonhematopoietic cells, suggesting that BMDCs may contribute to the maintenance of multiple tissues. Donor-derived bone marrow cells have been… (More)

Endometrial cells derived from donor stem cells in bone marrow transplant recipients.

Hugh S. Taylor
JAMA
2004

CONTEXT Regeneration of the endometrium in each menstrual cycle is required for reproduction. Endogenous endometrial stem cells reside in the basalis layer and serve as a source of cells that… (More)

Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium.

Banghyun Lee, Hongling Du, Hugh S. Taylor
Biology of reproduction
2009

The eutopic endometrium in women with endometriosis demonstrates diminished endometrial receptivity and altered gene expression. It is unknown if the endometrium being defective gives rise to a… (More)

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells

Yuan Gao, Fuju Wu, +14 authors Yingqun Huang
Nucleic acids research
2014

The H19 lncRNA has been implicated in development and growth control and is associated with human genetic disorders and cancer. Acting as a molecular sponge, H19 inhibits microRNA (miRNA) let-7. Here… (More)

Endocrine regulation of HOX genes.

Gaurang S. Daftary, Hugh S. Taylor
Endocrine reviews
2006

Hox genes have a well-characterized role in embryonic development, where they determine identity along the anteroposterior body axis. Hox genes are expressed not only during embryogenesis but also in… (More)

In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer.

Leo F. Doherty, Jason Gabriel Bromer, Yuping Zhou, Tamir S. Aldad, Hugh S. Taylor
Hormones & cancer
2010

Diethylstilbestrol (DES) and bisphenol-A (BPA) are estrogen-like endocrine-disrupting chemicals that induce persistent epigenetic changes in the developing uterus. However, DES exposure in utero is… (More)

Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium.

Hugh S. Taylor, Peter Igarashi, David L. Olive, Aydin Arici
The Journal of clinical endocrinology and…
1999

Under the influence of sex steroids, human endometrium undergoes sequential development in preparation for implantation. Hoxa11 is essential for implantation in the mouse. Here we describe a… (More)

Ischemia/reperfusion injury promotes and granulocyte-colony stimulating factor inhibits migration of bone marrow-derived stem cells to endometrium.

Hongling Du, Hanyia Naqvi, Hugh S. Taylor
Stem cells and development
2012

The endometrium is a dynamic tissue that undergoes repeated rounds of regeneration in each reproductive (estrous or menstrual) cycle. We have previously shown that bone marrow (BM)-derived stem cells… (More)

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