Hugh Ross

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Uptakes of neutral L-amino acids into rabbit choroid plexus apical membrane vesicles were studied using L-[14C]amino acids. Apical membrane vesicles were prepared using Ca2+ precipitation and uptakes of 14C-labeled substrates were measured by a rapid mixing and filtration procedure. Na-dependent, concentrative uptake was observed for proline, histidine and(More)
BACKGROUND Bcl-2 family genes are frequently amplified in small cell lung cancer (SCLC). A phase I trial was conducted to evaluate the safety of obatoclax, a Bcl-2 family inhibitor, given in combination with standard chemotherapy. METHODS Eligible patients (3-6 per cohort) had extensive-stage SCLC, measurable disease, ≤ 1 before therapy, Eastern(More)
For physical life to be possible in the universe, several characteristics must take on specific values, and these are listed below. 1 In the case of several of these characteristics, and given the intricacy of their interrelationships, the indication of divine "fine tuning" seems incontrovertible. 1. Strong nuclear force constant 2. Weak nuclear force(More)
Leptin, the gene product of adipose tissue that signals caloric plentitude via central nervous system receptors, may also have diverse peripheral metabolic actions. Of paramount interest has been the potential interaction(s) between leptin and insulin. Insofar as insulin alters leptin secretion/action (or vice versa), dysregulation of this system could(More)
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