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BACKGROUND Previous studies have shown increases in experimental pain during induction of a negative emotion with visual stimuli, verbal statements or unpleasant odours. The goal of the present study was to analyse the spatio-temporal activation patterns underlying pain augmentation during negative emotional sounds. METHODS Negative (e.g., crying),(More)
The activities of several enzymes involved in the metabolism of aspartate and glutamate were measured in striatal (nucleus caudatus and putamen) homogenates 2-3, 6-7, and 35-40 days following frontoparietal and frontal cortical ablation. The activity of glutamine synthetase (GS) was substantially increased (46-48%) on the operated side 6-7 days following(More)
Cerebrocortical synaptosomes were incubated with glutamine together with 6-diazo-5-oxo-L-norleucine (DON) and NH4Cl (which are known to inhibit phosphate-stimulated glutaminase) in order to assess the effect of such inhibition on the pool sizes and extent of evoked release of endogenous amino acids, particularly glutamate. DON (5 mM) inhibited glutaminase(More)
Radiolabelled glutamine and glucose were infused into lateral ventricles of rats in order to label transmitter amino acid pools in vivo. Brain regions close to the lateral ventricle (hippocampus, corpus striatum, hypothalamus) were labelled more effectively than more distant structures such as cerebral cortex or cerebellum. All regions were labelled to much(More)
In anesthetized dogs the popliteal lymph node alone, and the popliteal and iliac lymph nodes in series, have been perfused with solutions containing dog erythrocytes and streptococci. The perfusions have been carried out under conditions of lymph flow and pressure within the limits of those occurring in the actively moving dog, or after a severe degree of(More)
In an admirable account of the variations that occur in the bacterial species B. influenzae, Pittman (1) has described recently two forms. One form grows as a smooth colony, is virulent for animals, forms a soluble substance which precipitates the corresponding antiserum and the organisms tend to be uniform in size and appear to have a capsule-this is the S(More)
It could be said with little fear of contradiction that the hemolytic streptococcus presents a more hazy picture to bacteriologists and immunologists than does an organism like the pneumococcus. Its study presents many difficulties. In the first place, many strains which are pathogenic for man may show little or no primary virulence for animals. In the(More)