Hugh C Middleton

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Patients sustaining lesions of the orbital prefrontal cortex (PFC) exhibit marked impairments in the performance of laboratory-based gambling, or risk-taking, tasks, suggesting that this part of the human PFC contributes to decision-making cognition. However, to date, little is known about the particular regions of the orbital cortex that participate in(More)
Rationale: Altered serotonergic and dopaminergic function have been widely implicated in behavioural disorders associated with impulsivity and risk-taking. However, little research has addressed the specific cognitive consequences of changed monoaminergic function that might contribute to the production of impulsive behaviour. Objectives and methods: We(More)
The noradrenergic system has repeatedly been implicated in the mediation of attentional processes. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 µg/kg and 2.5 µg/kg) of theα 2 adreno ceptor agonist clonidine (CLO) on performance of various computerised tests of attention and learning in(More)
Theα 2 adrenoceptor has recently been implicated in working memory (WM), a function dependent on the integrity of the prefrontal cortex. Using a double-blind, placebo-controlled design, the present investigation examines the effects of two doses (1.5 µg/kg and 2.5 µg/kg) of the mixedα 1/α 2 adrenoceptor agonist clonidine (CLO) on performance of various(More)
As the catecholamines have long been implicated in attentional processes, the present investigation compared the effects of the mixedα 1/α 2 adrenoceptor agonist clonidine (CLO), the benzodiazepine diazepam (DZP), the D1/D2 antagonist haloperidol (HAL) and a low-tryptophan drink (Lo-TRP) on performance of tests of selective attention with distractors in(More)
Recent studies have shown that cognitive therapy is an effective treatment for panic disorder. However, little is known about how cognitive therapy compares with other psychological and pharmacological treatments. To investigate this question 64 panic disorder patients were initially assigned to cognitive therapy, applied relaxation, imipramine (mean 233(More)
BACKGROUND Improved management of mental illness and substance misuse comorbidity is a National Health Service priority, but little is known about its prevalence and current management. AIMS To measure the prevalence of comorbidity among patients of community mental health teams (CMHTs) and substance misuse services, and to assess the potential for joint(More)
Several investigations have revealed substantial influences of pharmacological manipulation of central noradrenergic activity upon performance in cognitive tests sensitive to frontal lobe dysfunction. They suggest a significant role for the noradrenergic coeruleo-cortical projection in cognitive function but conflicting findings and the complex pharmacology(More)
BACKGROUND Little is known about patients' perceptions of newer hypnotics. AIM To investigate use, experience, and perceptions of Z drug and benzodiazepine hypnotics in the community. DESIGN OF STUDY Cross-sectional survey of general practice patients who had received at least one prescription for a Z drug or benzodiazepine in the previous 6 months. (More)
Physiological response stereotypy is a well-established psychophysiological construct. Unfortunately, specifying parameters of tasks that evoke differing physiological responses has proved difficult. We have recorded cardiovascular activity while subjects carried out executive and attentional tasks that differed not only psychologically but also in their(More)