Hugh B. Nicholas

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We have developed a two-level case-based reasoning architecture for predicting protein secondary structure. The central idea is to break the problem into two levels: first, reasoning at the object (protein) level, and using the global information from this level to focus on a more restricted problem space; second, decomposing objects into pieces (segments),(More)
The MaxSegs algorithm has been distributed between a Cmy Y-AfP and a Thinking Machines CM-2 system at the Pittsbu~h %percomputing Center (PSC) to allow mpid and rigorous comparison of gene and prv-tein sequences with larye libnzries of other sequences. Thi~ achieves a. speedu,p factor of 5 to 10 in elapsed time. Users intervene at critical points in the(More)
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