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Understanding ligand binding effects on the conformation of estrogen receptor alpha-DNA complexes: a combinational quartz crystal microbalance with dissipation and surface plasmon resonance study.
Estrogen receptors are ligand-activated transcription factors that regulate gene expression by binding to specific DNA sequences. To date, the effect of ligands on the conformation of estrogenExpand
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Characterization of protein--DNA interactions using surface plasmon resonance spectroscopy with various assay schemes.
Specific protein-DNA interactions play a central role in transcription and other biological processes. A comprehensive characterization of protein-DNA interactions should include information aboutExpand
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Multiplatform genome-wide identification and modeling of functional human estrogen receptor binding sites
BackgroundTranscription factor binding sites (TFBS) impart specificity to cellular transcriptional responses and have largely been defined by consensus motifs derived from a handful of validatedExpand
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Femtomol SPR detection of DNA-PNA hybridization with the assistance of DNA-guided polyaniline deposition.
The inability of surface plasmon resonance (SPR) spectroscopy to detect extremely small refractive index changes has hindered its applications in ultrasensitive DNA analysis. In this study we reportExpand
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Natural Organochlorines as Precursors of 3-Monochloropropanediol Esters in Vegetable Oils.
During high-temperature refining of vegetable oils, 3-monochloropropanediol (3-MCPD) esters, possible carcinogens, are formed from acylglycerol in the presence of a chlorine source. To investigateExpand
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Profiling of metabolites in oil palm mesocarp at different stages of oil biosynthesis.
Oil palm is one of the most productive oil producing crops and can store up to 90% oil in its fruit mesocarp. However, the biosynthetic regulation and drivers of palm mesocarp development are stillExpand
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Combinational application of surface plasmon resonance spectroscopy and quartz crystal microbalance for studying nuclear hormone receptor-response element interactions.
Conventional methodologies for studying protein-DNA complexes, such as electrophoretic mobility shift assays (EMSAs), lack the real-time sensitivity and precision to accurately characterize theExpand
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Enzyme-based colorimetric detection of nucleic acids using peptide nucleic acid-immobilized microwell plates.
The development of label-free or nonlabeling assays for nucleic acids is important in basic biological research and biomedical diagnosis. In this study, we have developed an enzyme-based colorimetricExpand
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Electrochemical biosensing of DNA with capture probe covalently immobilized onto glassy carbon surface
Abstract In this study, an electrochemical DNA biosensor was developed based on the recognition of target DNA by hybridization detection with immobilized capture synthesized 21-mer single-strandedExpand
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Differential Metabolite Profiles during Fruit Development in High-Yielding Oil Palm Mesocarp
To better understand lipid biosynthesis in oil palm mesocarp, in particular the differences in gene regulation leading to and including de novo fatty acid biosynthesis, a multi-platform metabolomicsExpand
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