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BACKGROUND Bone metastases are a major burden in men with advanced prostate cancer. We compared denosumab, a human monoclonal antibody against RANKL, with zoledronic acid for prevention of skeletal-related events in men with bone metastases from castration-resistant prostate cancer. METHODS In this phase 3 study, men with castration-resistant prostate(More)
This double-blind study investigated the efficacy and safety of rapid-acting intramuscular olanzapine in treating agitation associated with Alzheimer's disease and/or vascular dementia. At 2 h, olanzapine (5.0 mg, 2.5 mg) and lorazepam (1.0 mg) showed significant improvement over placebo on the PANSS Excited Component (PANSS-EC) and Agitation-Calmness(More)
covering 0.6 to 22 GHz is presented in this paper. Cascode gain cells and m-derived matching sections are used to enhance the gain and bandwidth performance. The DA chip achieves measured gain of 7.3 f 0.8 dB with chip area of 0.9 x 1.5 mm' including testing pads. The amplifier was fabricated in a standard 0.18-pm CMOS technology and demonstrated the(More)
Abstrocr-Two broadband transimpedance amplifiers (TIAs) for optical applications were realized in a O.18-pm CMOS technology. The first n A cascading two three-stage cascode distributed amplifiers achieves a transimpedance gain of 58 dBR and a bandwidth of15 GHz. The other usinga caseode distributed amplifier achieves a transimpedance gain of 43 dBQ and a(More)
Absnod-A SiCe BiCMOS broadband mixer and analog multiplier using LC ladder matching nehuorks and atteauPtioacompensatioa method were first p r o p d. This broadband mixer achieves measured Conversion gain of 19 dB with a 3-dB bandwidth from 0.
—An ultra-wideband mixer using standard comple-mentery metal oxide semiconductor (CMOS) technology was first proposed in this paper. This broadband mixer achieves measured conversion gain of 11 1 5 dB with a bandwidth of 0.3 to 25 GHz. The mixer was fabricated in a commercial 0.18-m CMOS technology and demonstrated the highest frequency and bandwidth of(More)
A D-band (110 to 170GHz) CMOS push-push VCO is presented in this paper. Implemented in standard 0.13µm CMOS technology, the VCO has a 114GHz output signal with a phase noise of –107.6dBc/Hz at 10MHz offset, and a power consumption of 8.4mW from a 1.2V supply. Millimeter wave (MMW) VCO design is motivated by the need for the ever-increasing frequency and(More)
A broadband cascaded multi-stage distributed amplifier (CMSDA) is proposed and implemented in a standard 90nm CMOS technology. The standard CMOS technology can offer gain, bandwidth, and power performances comparable to advanced compound semiconductor technologies [1]-[4]. The CMOS CMSDA can achieve better than 7dB gain with a bandwidth of 70GHz. The(More)